NDLI: Genetic Diversity in Exon 2 of the Major Histocompatibility Complex Class II DQB1 Locus in Nigerian Goats

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Genetic Diversity in Exon 2 of the Major Histocompatibility Complex Class II DQB1 Locus in Nigerian Goats

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Genetic Diversity in Exon 2 of the Major Histocompatibility Complex Class II DQB1 Locus in Nigerian Goats

Content Provider	Springer Nature Link
Author	Yakubu, Abdulmojeed Salako, Adebowale E. Donato, Marcos Takeet, Michael I. Peters, Sunday O. Adefenwa, Mufliat A. Okpeku, Moses Wheto, Mathew Agaviezor, Brilliant O. Sanni, Timothy M. Ajayi, Oyeyemi O. Onasanya, Gbolabo O. Ekundayo, Oludotun J. Ilori, Babatunde M. Amusan, Samuel A. Imumorin, Ikhide G.
Copyright Year	2013
Abstract	The DQB1 locus is located in the major histocompatibility complex (MHC) class II region and involved in immune response. We identified 20 polymorphic sites in a 228 bp fragment of exon 2, one of the most critical regions of the MHC DQB1 gene, in 60 Nigerian goats. Four sites are located in the peptide binding region, and 10 amino acid substitutions are peculiar to Nigerian goats, compared with published sequences. A significantly higher ratio of nonsynonymous/synonymous substitutions (d N/d S) suggests that allelic sequence evolution is driven by balancing selection (P < 0.01). In silico functional analysis using PANTHER predicted that substitution P56R, with a subPSEC score of −4.00629 (Pdeleterious = 0.73229), is harmful to protein function. The phylogenetic tree from consensus sequences placed the two northern breeds closer to each other than either was to the southern goats. This first report of sequence diversity at the DQB1 locus for any African goat breed may be useful in the search for disease-resistant genotypes.
Starting Page	954
Ending Page	966
Page Count	13
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	51
Issue Number	11-12
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2013-07-09
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Genetic diversity Exon 2 DQB1 gene MHC class II Nigerian goats SNPs Human Genetics Biochemistry Zoology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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