NDLI: Polymorphic Variation of CYP1A1 and CYP1B1 Genes in a Haryana Population

Content Provider	Springer Nature Link
Author	Giri, Shiv Kumar Yadav, Anita Kumar, Anil Dev, Kapil Gulati, Sachin Gupta, Ranjan Aggarwal, Neeraj Gautam, Sanjeev Kumar
Copyright Year	2013
Abstract	Cytochrome P450 (CYP) 1A1 and CYP1B1 are important phase I xenobiotic metabolizing enzymes involved in the metabolism of numbers of toxins, endogenous hormones, and pharmaceutical drugs. Polymorphisms in these phase I genes can alter enzyme activity and are known to be associated with cancer susceptibility related to environmental toxins and hormone exposure. Their genotypes may also display ethnicity-dependent population frequencies. The present study was aimed to determine the frequencies of commonly known functional polymorphisms of CYP1A1 and CYP1B1 genes in a Haryana state population of North India. The allelic frequency of CYP1A1 polymorphism m1 (MspI) was 29.65% and m2 (Ile462Val) was 24.85%. The frequency of CYP1B1 polymorphism m1 (Val432Leu) was 45.85% and m2 (Asn453Ser) was 16.2%. We observed inter- and intra-ethnic variation in the frequency distribution of these polymorphisms. Analysis of polymorphisms in these genes might help in predicting the risk of cancer. Our results emphasize the need for more such studies in high-risk populations.
Starting Page	853
Ending Page	864
Page Count	12
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	51
Issue Number	11-12
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2013-07-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CYP1A1 CYP1B1 Polymorphism Haryana population Allele frequency Cancer Human Genetics Biochemistry Zoology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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