NDLI: Local Base Order Influences the Origin of ccr5 Deletions Mediated by DNA Slip Replication

Please wait, while we are loading the content...

Genetic Background Influences P/Q-type Ca2+ Channel α1A Subunit mRNA Expression in Olfactory Bulb and Reproductive Ability of N-type Ca2+ Channel α1B Subunit-Deficient Mice

Polymorphic Study of Equine Antiviral MXA Gene

Population Genetic Structure of the Yangtze Finless Porpoise (Neophocaena phocaenoides asiaeorientalis): Implications for Management and Conservation

Mice with the Enhanced Green Fluorescent Protein Gene Knocked in to Chromosome 11 Exhibit Normal Transmission Ratios

Biochemical Genetics : Volume 43, Issue 3-4, April 2005

Biochemical Genetics : Volume 43, Issue 1-2, February 2005

Biochemical Genetics : Volume 42

Biochemical Genetics : Volume 41

Biochemical Genetics : Volume 40

Biochemical Genetics : Volume 39

Biochemical Genetics : Volume 38

Biochemical Genetics : Volume 37

Biochemical Genetics : Volume 36

Biochemical Genetics : Volume 35

Local Base Order Influences the Origin of ccr5 Deletions Mediated by DNA Slip Replication

Content Provider	Springer Nature Link
Author	Zhang, Chi Yu Wei, Ji Fu He, Shao Heng
Copyright Year	2005
Abstract	CCR5 is a seven-transmembrane G-protein-coupled receptor that binds the CC-chemokines including RANTES, eotaxin, MIP-1α and β. CCR5 serves as an essential coreceptor for cell entry of R5 (macrophage-tropic, nonsyncytium-inducing) strains of HIV-1. To date, four deletions have been found in human and primate ccr5. There is little evidence, however, on how these deletion mutations occur. In the present study, we analyzed ccr5 sequences of both mutants and wild type and found that direct repeats flanked the breakpoints of the deletions, suggesting that these deletions resulted from slipped mispairing during DNA replication. Of particular interest was the location of these deletions in or near the regions with higher negative FORS-D values. High negative FORS-D values stand for high stem-loop potential determined by base order and influence mainly the formation of stem-loop structures. Therefore, the particular location of these deletions suggests that the local sequence of bases might be important in the initiation of deletions mediated by DNA slip replication in concert with direct repeats.
Starting Page	229
Ending Page	237
Page Count	9
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	43
Issue Number	5-6
e-ISSN	15734927
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2005-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ccr5 deletion direct repeats stem-loop potential slip replication Human Genetics Medical Microbiology Biochemistry Zoology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Proliferation of direct repeats near the Oenothera chloroplast DNA origin of replication.

Evaluation of FORS-D Analysis: A Comparison with the Statistically Significant Stem-loop Potential

Secondary structure of the human mitochondrial genome affects formation of deletions

Mitochondrial diversity and the origin of Iberian sheep

DNA Evidence of the Origin of Varroa jacobsoni Oudemans in the Americas

The Origin of the White Roman Goose

Number of STR Repeats as a Potential New Quantitative Genetic Marker for Complex Diseases, Illustrated by Schizophrenia

Neural Stem Cells as Potential Glioblastoma Cells of Origin.

Mitochondrial diversity and the origin of Iberian sheep

Local Base Order Influences the Origin of ccr5 Deletions Mediated by DNA Slip Replication

Similar Documents

Proliferation of direct repeats near the Oenothera chloroplast DNA origin of replication.

Evaluation of FORS-D Analysis: A Comparison with the Statistically Significant Stem-loop Potential

Secondary structure of the human mitochondrial genome affects formation of deletions

Mitochondrial diversity and the origin of Iberian sheep

DNA Evidence of the Origin of Varroa jacobsoni Oudemans in the Americas

The Origin of the White Roman Goose

Number of STR Repeats as a Potential New Quantitative Genetic Marker for Complex Diseases, Illustrated by Schizophrenia

Neural Stem Cells as Potential Glioblastoma Cells of Origin.

Mitochondrial diversity and the origin of Iberian sheep

Local Base Order Influences the Origin of ccr5 Deletions Mediated by DNA Slip Replication