NDLI: Neural Stem Cells as Potential Glioblastoma Cells of Origin.

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Neural Stem Cells as Potential Glioblastoma Cells of Origin.

Content Provider	Europe PMC
Author	Loras, Alba Gonzalez-Bonet, Luis G. Gutierrez-Arroyo, Julia L. Martinez-Cadenas, Conrado Marques-Torrejon, Maria Angeles
Editor	Mandrioli, Jessica
Copyright Year	2023
Abstract	Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high rates of invasiveness. Therefore, patients face poor prognosis, and the survival rates remain very low. Previous research states that GBM contains a cell population with stem cell characteristics called glioma stem cells (GSCs). These cells are able to self-renew and regenerate the tumor and, therefore, they are partly responsible for the observed resistance to therapies and tumor recurrence. Recent data indicate that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells of origin of GBM, that is, the cell type acquiring the initial tumorigenic mutation. The involvement of SVZ-NSCs is also associated with GBM progression and recurrence. Identifying the cellular origin of GBM is important for the development of early detection techniques and the discovery of early disease markers. In this review, we analyze the SVZ-NSC population as a potential GBM cell of origin, and its potential role for GBM therapies.
Volume Number	13
PubMed Central reference number	PMC10145968
Issue Number	4
PubMed reference number	37109434
Journal	Life (Basel)
e-ISSN	20751729
DOI	10.3390/life13040905
Language	English
Publisher	MDPI
Publisher Date	2023-03-29
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	glioblastoma neural stem cells cell of origin
Content Type	Text
Resource Type	Article
Subject	Paleontology Space and Planetary Science Biochemistry, Genetics and Molecular Biology Ecology, Evolution, Behavior and Systematics

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