NDLI: Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

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Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

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Characteristics of the β-Globin Gene Cluster Haplotypes of Three Han Chinese Populations at Beijing, Xi’an, and Kunming as Compared with Those of Other Asian Populations

Content Provider	Springer Nature Link
Author	Shimizu, Koji Nagaoka, Erika Okada, Yusuke Takeuchi, Yukiko Harihara, Shinji Omoto, Keiichi Imanishi, Tadashi Kim, Wook Shin, Dong Jik Hao, Luping Jin, Feng
Copyright Year	2008
Abstract	Haplotype frequencies of the β-globin gene cluster of Han Chinese at Beijing, Xi’an, and Kunming were estimated, and their mutual genetic relationships were examined and compared to those of Buryats, Khalkhs, Evenkis, Oroqens, Koreans, and Colombian Amerindians. A major 5′ subhaplotype (5′ to the δ-globin gene), a major 3′ subhaplotype (in and 3′ to the β-globin gene), and a major haplotype (combination of 5′ and 3′ subhaplotypes) are represented as + − − − −, − +, and + − − − − − +, respectively, and found in all three Han Chinese. A rare 5′ subhaplotype, − − − − −, which is one of the possible ancestral types, was found only in Han Chinese at Kunming at low frequency (0.013), and a rare 3′ subhaplotype, − −, was also observed in all three Han Chinese at low frequencies (0.009–0.014). The present haplotype frequency study suggested that the highest genetic affinity was found between Han Chinese at Beijing and those at Xi’an; the next highest was between Han Chinese at Beijing and Koreans, followed by that between Han Chinese at Beijing and Khalkhs, then that between Han Chinese at Xi’an and those at Kunming or Khalkhs, and finally that between Han Chinese at Beijing and those at Kunming. A genetic boundary between northern and southern Han Chinese was not evident in the present study.
Starting Page	566
Ending Page	582
Page Count	17
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	46
Issue Number	9-10
e-ISSN	15734927
Language	English
Publisher	Springer US
Publisher Date	2008-06-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	β-Globin gene cluster haplotype Han Chinese Asian populations Medical Microbiology Zoology Biochemistry Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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