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| Content Provider | Springer Nature Link |
|---|---|
| Author | Bürkle, Alexander |
| Copyright Year | 2000 |
| Abstract | Poly(ADP-ribosyl)ation is a posttranslationalmodification of nuclear proteins catalysed by the113-kDa enzyme poly(ADP-ribose) polymerase-1 (PARP-1)and, to a lesser extent, by several other recentlydescribed polypeptides. The catalytic function ofPARP-1 is directly stimulated by DNA strand breaks,thus making poly(ADP-ribosyl)ation one of theimmediate cellular responses to oxidative and othertypes of DNA damage. Poly(ADP-ribosyl)ation plays animportant role in the recovery of proliferating cellsfrom certain types of DNA damage, and this has beenlinked mechanistically with an involvement in DNAbase-excision repair. Furthermore PARP-1 activity isnecessary to maintain genomic stability underconditions of genotoxic stress and is actually a keyregulator of alkylation-induced sister-chromatidexchange formation, imposing a control that isstrictly negative and commensurate with the enzymeactivity level. Finally, there is a positivecorrelation between the poly(ADP-ribosyl)ationcapacity of mononuclear leukocytes of variousmammalian species and species-specific life span.Likewise, lymphoblastoid cell lines derived from humancentenarians display a higher poly(ADP-ribosyl)ationcapacity than controls. In conclusion, PARP-1 may beviewed as a factor that is responsible for downregulating therate of genomic instability events, which are provokedby the constant attack by endogenous and exogenousDNA-damaging agents, in such a way as to tune them toa level which is just appropriate for the life spanpotential of a given species. |
| Starting Page | 41 |
| Ending Page | 46 |
| Page Count | 6 |
| File Format | |
| ISSN | 13895729 |
| Journal | Biogerontology |
| Volume Number | 1 |
| Issue Number | 1 |
| e-ISSN | 15736768 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2000-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Geriatrics/Gerontology Proteomics Cell Biology Developmental Biology Animal Anatomy / Morphology / Histology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Gerontology Geriatrics and Gerontology |
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