NDLI: Longevity and the immune response

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Longevity in vitro of human CD4+ T helper cell clonesderived from young donors and elderly donors, or fromprogenitor cells: age-associated differences in cellsurface molecule expression and cytokine secretion

Cytoplasmic genomes that confer additionallongevity in Drosophila melanogaster

Possible role of subunit A of nuclearfactor Y (NF-YA) in normal human diploidfibroblasts during senescence

Longevity and the immune response

Consideration of heteroduplexes and homoduplexes forthe quantification by competitive PCR of humanmitochondrial DNA deletions with ageing of tissues and cells

ProtAge: role of proteasome in human ageing. Implications for anti-ageing strategies. A shared cost RTD project of the EU's 5th framework

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International Symposium on 'Aging - a Challenge in the New Millennium' and X-Biennial Meeting of the Association of Gerontology (India), 10-12 November 2000, Banaras Hindu University, Varanasi, India

Biogerontology : Volume 1, Issue 2, June 2000

Biogerontology : Volume 1, Issue 1, March 2000

Longevity and the immune response

Content Provider	Springer Nature Link
Author	Aspinall, Richard
Copyright Year	2000
Abstract	The domino hypothesis of the onset of age associatedimmune insufficiency suggests that it is theconsequence of a cascade of events beginning withinvolution of the thymus. Involution is associatedwith a reduced thymic output leading to fewernaïve T cells contributing to the peripheral T-cell pool. Homeostatic mechanisms, which maintain thenumber of T cells in the peripheral pool withinprecise limits, induce the proliferation and prolongthe survival of resident T cells to fill the nichesleft vacant by the absent naïve T cells. In thishypothesis, falling thymic output would be matched byresident T-cell proliferation and with age theseproliferating cells will reach their replicativelimit. Their prolonged survival will lead to theaccumulation of cells unable to replicate, producinga decline in immune function and a susceptibility toinfection, or certain cancers.Comparison of gender differences in life-span andrates of death in each age group due to infectious orparasitic disease suggests that the immune system infemales works more efficiently and effectively forlonger than the immune system in males. This leads tothe suggestion that involution of the thymus, andhence thymic output, occurs more rapidly in males thanin females.
Starting Page	273
Ending Page	278
Page Count	6
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	1
Issue Number	3
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2000-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geriatrics/Gerontology Proteomics Cell Biology Developmental Biology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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Acknowledgements

Acknowledgements

Participation theory of aging

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Acknowledgements

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Longevity and the immune response