NDLI: Immunomodulatory synthetic dipeptide L-Glu-L-Trp slowsdown aging and inhibits spontaneous carcinogenesis in rats

Content Provider	Springer Nature Link
Author	Anisimov, Vladimir N. Khavinson, Vladimir Kh. Morozov, Vyacheslav G.
Copyright Year	2000
Abstract	Immunomodulatory molecule L-Glu-L-Trp wasisolated from natural calf thymic peptide complexThymalin by reverse-phase high performance liquidchromatography. On the basis of the synthesizeddipeptide a pharmaceutical was designed containg this compound, which later receives the brand nameThymogen®. The agent activated T-celldifferentiation, T-cell recognition of peptide-MHCcomplexes, induced changes in intracellularcomposition of cyclic nucleotides, and activatedneutrophilic chemotaxis and phagocytosis. The effectof dipeptide on survival, life span and spontaneoustumor development was studied in female rats. Seventy-six, five-month-old outbred female rats were randomlysubdivided into two groups and were subcutaneouslyinjected with 0.2 ml of normal saline (controls, 32 rats) or with 5 µg/rat of the dipeptideL-Glu-L-Trp, dissolved in 0.2 ml of saline (44 rats),5 times per week for 12 months. Animals were monitoredup to their natural death and all the tumorsdiscovered were studied microscopically. Mean lifespan of rats in both groups was similar but that of10% maximum survived control rats constituted949 ± 16.1 days, whereas in the dipeptide-treatedrats this value was 1048 ± 21.1 days (P < 0.001).Six out of 44 rats treated with the drug survived overthe maximum life span of control rats (965 days). Theaging rate indicated as α in the Gompertz equation,was 0.0071 days−1 in controls and 0.0041 days−1 in rats exposed to L-Glu-L-Trp. Totaltumor incidence was 1.5 times lower (P < 0.01),malignant tumor incidence 1.7 times lower (P < 0.01),and hematopoietic malignancies (leukemias andlymphomas) 3.4 times lower (P < 0.02) in rats exposedto the dipeptide in comparison with controls. Thus,treatment with L-Glu-L-Trp delayed aging rate anddecreased spontaneous tumor incidence in rats.
Starting Page	55
Ending Page	59
Page Count	5
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	1
Issue Number	1
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2000-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geriatrics/Gerontology Proteomics Cell Biology Developmental Biology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Acknowledgements

Acknowledgements

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Acknowledgements

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