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| Content Provider | Springer Nature Link |
|---|---|
| Author | Hadi, Fazal Dato, Serena Carpi, Francesco M. Prontera, Paolo Crucianelli, Francesca Renda, Federica Passari, Giuseppe Napolioni, Valerio |
| Copyright Year | 2015 |
| Abstract | Several recent lines of evidence are proving an important role for dopamine in the aging process and in the determination of life span. Components of the dopaminergic system may represent good candidates for longevity studies. Herein, we tested the possible association of the functional SLC6A3/DAT1 40-bp VNTR with life-expectancy in a healthy population of Central Italy (N = 993) by applying a genetic-demographic approach that takes into account the demographic information and different survival rates between sexes for modeling the survival of specific allele carriers in the population. Male carriers of S*/S* genotype showed a lower survival chance across most of the lifespan respect to the survival of DAT1*L-carriers (P = 0.021). The same analyses gave non-significant results in females. Several studies already reported significant sex differences in dopamine metabolism and its related biological pathways. Thus, we can hypothesize that the SLC6A3/DAT1 40 bp-VNTR may affect life expectancy in a sex-specific way. Moreover, it is conceivable that DAT1 S*/S* carriers, who are prone to assume “risk” type behaviors, may be dropped out of the “healthy” population by a sort of “demographic selection”. |
| Starting Page | 365 |
| Ending Page | 373 |
| Page Count | 9 |
| File Format | |
| ISSN | 13895729 |
| Journal | Biogerontology |
| Volume Number | 16 |
| Issue Number | 3 |
| e-ISSN | 15736768 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-01-24 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | DAT1 Polymorphism Longevity Gender Dopamine Cell Biology Geriatrics/Gerontology Developmental Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Gerontology Geriatrics and Gerontology |
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