NDLI: Lack of replication of genetic associations with human longevity

Content Provider	Springer Nature Link
Author	velli, Valeria Viviani Anselmi, Chiara Roncarati, Roberta Guffanti, Guia Malovini, Alberto Piluso, Giulio Puca, Annibale Alessandro
Copyright Year	2007
Abstract	The exceptional longevity of centenarians is due in part to inherited genetic factors, as deduced from data that show that first degree relatives of centenarians live longer and have reduced overall mortality. In recent years, a number of groups have performed genetic association studies on long-living individuals (LLI) and young controls to identify alleles that are either positively or negatively selected in the centenarian population as consequence of a demographic pressure. Many of the reported studies have shown genetic loci associated with longevity. Of these, with the exception of APOE, none have been convincingly reproduced. We validated our populations by typing the APOE locus. In addition, we used 749 American Caucasian LLI, organized in two independent tiers and 355 American Caucasian controls in the attempt to replicate previously published findings. We tested Klotho (KL)-VS variant (rs952706), Cholesteryl Ester Transfer Protein (CETP) I405V (rs5882), Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (rs2542052), Microsomal Transfer Protein (MTP) -493G/T (rs2866164) and apolipoprotein E (APOE) ε2 and ε4 isoforms, (rs7412 and rs429358) haplotypes respectively. Our results show that, at present, except for APOE, none of the selected genes show association with longevity if carefully tested in a large cohort of LLI and their controls, pointing to the need of larger populations for case–control studies in extreme longevity.
Starting Page	85
Ending Page	92
Page Count	8
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	9
Issue Number	2
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2007-11-23
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Association studies Long living individuals Longevity Developmental Biology Geriatrics/Gerontology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Gender-specific association of ADA genetic polymorphism with human longevity

Cellular degradation activity is maintained during aging in long-living queen bees

Inflammation, genetic background and longevity

Immunosenescence and human longevity

Assessing Genetic Association with Human Survival at Multi-Allelic Loci

Lack of hypergravity-associated longevity extension in Drosophila melanogaster flies overexpressing hsp70

Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study

Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes

Chaperones and Longevity

Lack of replication of genetic associations with human longevity

Similar Documents

Gender-specific association of ADA genetic polymorphism with human longevity

Cellular degradation activity is maintained during aging in long-living queen bees

Inflammation, genetic background and longevity

Immunosenescence and human longevity

Assessing Genetic Association with Human Survival at Multi-Allelic Loci

Lack of hypergravity-associated longevity extension in Drosophila melanogaster flies overexpressing hsp70

Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study

Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes

Chaperones and Longevity

Lack of replication of genetic associations with human longevity