NDLI: Beneficial effects of melatonin in a rat model of sporadic Alzheimer’s disease

Content Provider	Springer Nature Link
Author	Rudnitskaya, Ekaterina A. Maksimova, Kseniya Yi. Muraleva, Natalia A. Logviv, Sergey V. Yanshole, Lyudmila V. Kolosova, Nataliya G. Stefava, Natalia A.
Copyright Year	2014
Abstract	Melatonin synthesis is disordered in patients with Alzheimer’s disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In the present study, we demonstrate that disturbances in melatonin secretion occur in OXYS rats at 4 months of age. These disturbances occur simultaneously with manifestation of behavioral abnormalities against the background of neurodegeneration and alterations in hormonal status but before the signs of amyloid-β accumulation. We examined whether oral administration of melatonin could normalize the melatonin secretion and have beneficial effects on OXYS rats before progression to AD-like pathology. The results showed that melatonin treatment restored melatonin secretion in the pineal gland of OXYS rats as well as the serum levels of growth hormone and IGF-1, the level of BDNF in the hippocampus and the healthy state of hippocampal neurons. Additionally, melatonin treatment of OXYS rats prevented an increase in anxiety and the decline of locomotor activity, of exploratory activity, and of reference memory. Thus, melatonin may be involved in AD progression, whereas oral administration of melatonin could be a prophylactic strategy to prevent or slow down the progression of some features of AD pathology.
Starting Page	303
Ending Page	316
Page Count	14
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	16
Issue Number	3
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-12-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease Melatonin Neurodegeneration OXYS rats Cell Biology Geriatrics/Gerontology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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