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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ma, Xingshun Eyler, Lisa T. Hu, Xiaomei Hou, Xiao Deng, Wei Zhang, Xiaowei Lin, Yin Lei, Wei Li, Mingli Kang, Line Huang, Yongfeng Wang, Na Qiu, Tian Li, Xiao He, Qian Fu, Yixiao Meng, Huaqing Li, Tao |
| Copyright Year | 2015 |
| Abstract | Cortical surface area (CSA) has particular relevance for understanding development, behavior, and the connection between brain structure and function. Little is known about genetic and environmental determinants of CSA during development. We utilized bivariate twin methods to identify global and regionally specific genetic factors which influence CSA in a preliminary sample of typically-developing adolescents, with hypotheses based on findings in middle-aged adults. Similar to previous findings, we observed high heritability for total CSA. There was also significant evidence for genetic influences on regional CSA, particularly when these were not adjusted for total CSA, with highest heritability in frontal cortex and relatively fewer genetic contributions to medial temporal cortical structures. Adjustment for total CSA reduced regional CSA heritability dramatically, but a moderate influence of genetic factors remained in some regions. Both global and regionally-specific genetic factors influence regional CSA during adolescence. |
| Starting Page | 205 |
| Ending Page | 216 |
| Page Count | 12 |
| File Format | |
| ISSN | 00018244 |
| Journal | Behavior Genetics |
| Volume Number | 46 |
| Issue Number | 2 |
| e-ISSN | 15733297 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-10-30 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Twin Adolescents Cortex Heritability Surface area Clinical Psychology Health Psychology Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical) |
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