NDLI: Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Content Provider	Springer Nature Link
Author	Berg, Stéphanie M. Moor, Marleen H. M. Verweij, Karin J. H. Krueger, Robert F. Lucia, Michelle Arias Vasquez, Alejandro Matteson, Lindsay K. Derringer, Jaime Esko, Tõnu Amin, Najaf Gordon, Scott D. Hansell, Narelle K. Hart, Amy B. Seppälä, Ilkka Huffman, Jennifer E. Konte, Bettina Lahti, Jari Lee, Minyoung Miller, Mike Nutile, Teresa Tanaka, Toshiko Teumer, Alexander Viktorin, Alexander Wedeja, Juho Abdellaoui, Abdel Abecasis, Goncalo R. Adkins, Daniel E. Agrawal, Arpana Allik, Jüri Appel, Katja Bigdeli, Timothy B. Busonero, Fabio Campbell, Harry Costa, Paul T. Smith, George Davey Davies, Gail Wit, Harriet Ding, Jun Engelhardt, Barbara E. Eriksson, Johan G. Fedko, Iryna O. Ferrucci, Luigi Franke, Barbara Giegling, Ina Grucza, Richard Hartmann, Annette M. Heath, Andrew C. Heinen, Kati Henders, Anjali K. Homuth, Georg Hottenga, Jouke Jan Iaco, William G. Janzing, Joost Jokela, Markus Karlsson, Robert Kemp, John P. Kirkpatrick, Matthew G. Latvala, Antti Lehtimäki, Terho Liewald, David C. Madden, Pamela A. F. Magri, Chiara Magnusson, Patrik K. E. Marten, Jonathan Maschio, Andrea Mbarek, Hamdi Medland, Sarah E. Mihailov, Evelin Milaneschi, Yuri Montgomery, Grant W. Nauck, Matthias Nivard, Michel G. Ouwens, Klaasjan G. Palotie, Aar Pettersson, Erik Polasek, Ozren Qian, Yong Pulkki Råback, Laura Raitakari, Olli T. Realo, Anu Rose, Richard J. Ruggiero, Daniela Schmidt, Carsten O. Slutske, Wendy S. Sorice, Rossella Starr, John M. St Pourcain, Beate Sutin, Angelina R. Timpson, Nicholas J. Trochet, Holly Vermeulen, Sita Vuoksimaa, Eero Widen, Elisabeth Wouda, Jasper Wright, Margaret J. Zgaga, Lina Porteous, David Minelli, Alessandra Palmer, Abraham A. Rujescu, Dan Ciullo, Marina Hayward, Caroline Rudan, Igor Metspalu, Andres Kaprio, Jaakko Deary, Ian J. Räikkönen, Katri Wilson, James F. Keltikangas Järvinen, Liisa Bierut, Laura J. Hettema, John M. Grabe, Hans J. Penninx, Brenda W. J. H. van Duijn, Cornelia M. Evans, David M. Schlessinger, David Pedersen, Nancy L. Terraccia, Antonio McGue, Matt Martin, Nicholas G. Boomsma, Dorret I.
Copyright Year	2015
Abstract	Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
Starting Page	170
Ending Page	182
Page Count	13
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	46
Issue Number	2
e-ISSN	15733297
Language	English
Publisher	Springer US
Publisher Date	2015-09-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Personality Phenotype harmonization Common genetic variants Imputation Polygenic risk Clinical Psychology Health Psychology Public Health
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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