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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kläning, Ulla Trumbetta, Susan L. Gottesman, Irving I. Skytthe, Axel Kyvik, Kirsten O. Bertelsen, Aksel |
| Copyright Year | 2015 |
| Abstract | We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region. |
| Starting Page | 193 |
| Ending Page | 204 |
| Page Count | 12 |
| File Format | |
| ISSN | 00018244 |
| Journal | Behavior Genetics |
| Volume Number | 46 |
| Issue Number | 2 |
| e-ISSN | 15733297 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-11-04 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Schizophrenia Genetics Twins Endophenotype Affective psychoses ICD-10 Denmark Clinical Psychology Health Psychology Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical) |
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