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| Content Provider | Springer Nature Link |
|---|---|
| Author | Duma, S. N. Rezakova, M. V. Mazhirina, K. G. Petrovskii, E. D. Pokrovskii, M. A. Dzhafarova, O. A. Savelov, A. A. Shtark, M. B. Epstein, O. I. |
| Copyright Year | 2015 |
| Abstract | Functional magnetic resonance imaging (fMRI) of the brain was applied for preclinical evaluation of the efficiency of Divaza preparation intended for the treatment of cerebrovascular disorders. Psychological testing (Stroop task) in the magnetic field of fMRI was performed before and after 12-week treatment course using a double blind placebo-controlled protocol. It was shown that standard psychological and neuropsychological protocols do not allow fully estimate the results of treatment, whereas fMRI targeted the pool of cerebral structures activated during task solution. In the treatment group (in contrast to placebo), active zones in these structures were found only during task solution. Thus, resolution capability of fMRI significantly extends the range of rational screening by identifying active zones and can radically change the procedure of selection and clinical trials. |
| Starting Page | 453 |
| Ending Page | 457 |
| Page Count | 5 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 158 |
| Issue Number | 4 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-02-24 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | release-active neuroprotective drugs release-active forms functional magnetic resonance imaging neuroimaging cognitive properties Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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