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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tyurenkov, I. N. Volotova, E. V. Kurkin, D. V. Mazina, N. V. Bakulin, D. A. Logviv, I. O. Antipova, T. A. |
| Copyright Year | 2015 |
| Abstract | We studied in vitro and in vivo neuroprotective and antioxidant properties of neuroglutam, a new glutamic acid derivative. In experiments on immortalized mouse hippocampal cell line HT22, neuroglutam exhibited a neuroprotective effect in the model of oxidative stress after its introduction, both before and after H2O2. In vivo study on animals treated with neuroglutam against the background of cerebral ischemia modeled by irreversible occlusion of the common carotid arteries showed that plasma level of TBA-active products was signifi cantly lower and activities of cell antioxidant enzymes (superoxide dismutase and catalase) were higher than in control animals receiving saline under the same conditions. |
| Starting Page | 365 |
| Ending Page | 367 |
| Page Count | 3 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 159 |
| Issue Number | 3 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-07-28 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | neuroprotective properties antioxidant system neuroglutam Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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