NDLI: Depressive Behavior and Monoamine Contents in Brain Structures of Rats During Chronic Overcrowding

Content Provider	Springer Nature Link
Author	Loseva, E. V. Sarkisova, K. Yu. Logiva, N. A. Kudrin, V. S.
Copyright Year	2015
Abstract	Effects of chronic overcrowding on the development of depressive-like behavior and changes in monoamine contents in the brain structures involved in the development of depression were studied in rats. It was shown that overcrowding increased grooming duration and did not change the number of crossed squares and postures in the open-field test. In the forced swimming test, overcrowding increased immobility time and deceased the duration of the first episode of active swimming, which attested to depressive-like behavior. Overcrowding reduced the content of dopamine in the striatum, its metabolites (homovanilic and dioxyphenylacetic acids) and dopamine metabolism rate in the hypothalamus, and increased the concentrations of norepinephrine, homovanilic acid, and dioxyphenylacetic acid in the olfactory bulb and homovanilic acid in the prefrontal cortex. No changes were found in the nucleus accumbens. Serotonin content did not change in all analyzed structures. It was hypothesized that the observed changes in the content of monoamines and their metabolites in certain brain structures could underlie the depressive-like behavior induced by overcrowding in rats.
Starting Page	327
Ending Page	330
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	159
Issue Number	3
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2015-07-28
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	depression overcrowding brain monoamines open-field test forced swimming test Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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