NDLI: Does melatonin influence the apoptosis in rat uterus of animals exposed to continuous light?

Content Provider	Springer Nature Link
Author	Ferreira, Cecília S. Carvalho, Kátia C. Maganhin, Carla C. Paiotti, Ana P. R. Oshima, Celina T. F. Simões, Manuel J. Baracat, Edmund C. Soares, José M.
Copyright Year	2015
Abstract	Melatonin has been described as a protective agent against cell death and oxidative stress in different tissues, including in the reproductive system. However, the information on the action of this hormone in rat uterine apoptosis is low. Our objective was to evaluate the effects of melatonin on mechanisms of cell death in uterus of rats exposed to continuous light stress. Twenty adult Wistar rats were divided into two groups: GContr (vehicle control) and GExp which were treated with melatonin (0.4 mg/mL), both were exposed to continuous light for 90 days. The uterus was removed and processed for quantitative real time PCR (qRT-PCR), using PCR-array plates of the apoptosis pathway; for immunohistochemistry and TUNEL. The results of qRT-PCR of GEXP group showed up-regulation of 13 and 7, pro-apoptotic and anti-apoptotic genes, respectively, compared to GContr group. No difference in pro-apoptotic proteins (Bax, Fas and Faslg) expression was observed by immunohistochemistry, although the number of TUNEL-positive cells was lower in the group treated with melatonin compared to the group not treated with this hormone. Our data suggest that melatonin influences the mechanism and decreases the apoptosis in uterus of rats exposed to continuous light.
Starting Page	155
Ending Page	162
Page Count	8
File Format	PDF
ISSN	13608185
Journal	Apoptosis
Volume Number	21
Issue Number	2
e-ISSN	1573675X
Language	English
Publisher	Springer US
Publisher Date	2015-11-05
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Melatonin Female rats Continuous light Apoptosis Cancer Research Cell Biology Oncology Biochemistry Virology
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science Biochemistry (medical) Cell Biology Clinical Biochemistry Cancer Research Pharmacology

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