NDLI: SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

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SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

Content Provider	Springer Nature Link
Author	Jia, Zhuqing Wang, Jiaji Shi, Qiong Liu, Siyu Wang, Weiping Tian, Yuyao Lu, Qin Chen, Ping Ma, Kangtao Zhou, Chunyan
Copyright Year	2015
Abstract	Sepsis-induced cardiac apoptosis is one of the major pathogenic factors in myocardial dysfunction. As it enhances numerous proinflammatory factors, lipopolysaccharide (LPS) is considered the principal mediator in this pathological process. However, the detailed mechanisms involved are unclear. In this study, we attempted to explore the mechanisms involved in LPS-induced cardiomyocyte apoptosis. We found that LPS stimulation inhibited microRNA (miR)-499 expression and thereby upregulated the expression of SOX6 and PDCD4 in neonatal rat cardiomyocytes. We demonstrate that SOX6 and PDCD4 are target genes of miR-499, and they enhance LPS-induced cardiomyocyte apoptosis by activating the BCL-2 family pathway. The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499. Overexpression of miR-499 protected the cardiomyocytes against LPS-induced apoptosis. In brief, our results demonstrate the existence of a miR-499-SOX6/PDCD4-BCL-2 family pathway in cardiomyocytes in response to LPS stimulation.
Starting Page	174
Ending Page	183
Page Count	10
File Format	PDF
ISSN	13608185
Journal	Apoptosis
Volume Number	21
Issue Number	2
e-ISSN	1573675X
Language	English
Publisher	Springer US
Publisher Date	2015-12-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	SOX6 PDCD4 LPS miR-499 Cardiomyocyte Apoptosis Cancer Research Cell Biology Oncology Biochemistry Virology
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science Biochemistry (medical) Cell Biology Clinical Biochemistry Cancer Research Pharmacology

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SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

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SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

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SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition

ORIGINAL PAPER SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition (2015)

LPS-induced apoptosis is dependent upon mitochondrial dysfunction

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SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition