NDLI: Inelasticity of Human Carotid Atherosclerotic Plaque

Content Provider	Springer Nature Link
Author	Maher, Eoghan Creane, Arthur Sultan, Sherif Hynes, Niamh Lally, Caitríona Kelly, Daniel J.
Copyright Year	2011
Abstract	Little mechanical test data exists regarding the inelastic behavior of atherosclerotic plaques. As a result finite element (FE) models of stenting procedures commonly use hyperelastic material models to describe the soft tissue response thus limiting the accuracy of the model to the expansion stage of stent implantation and leave them unable to predict the lumen gain. In this study, cyclic mechanical tests were performed to characterize the inelastic behavior of fresh human carotid atherosclerotic plaque tissue due to radial compressive loading. Plaques were classified clinically as either mixed (M), calcified (Ca), or echolucent (E). An approximately linear increase in the plastic deformation was observed with increases in the peak applied strain for all plaque types. While calcified plaques generally appeared stiffest, it was observed that the clinical classification of plaques had no significant effect on the magnitude of permanent deformation on unloading. The test data was characterized using a constitutive model that accounts for both permanent deformation and stress softening to describe the compressive plaque behavior on unloading. Material constants are reported for individual plaques as well as mean values for each plaque classification. This data can be considered as a first step in characterizing the inelastic behavior of atherosclerotic plaques and could be used in combination with future mechanical data to improve the predictive capabilities of FE models of angioplasty and stenting procedures particularly in relation to lumen gain.
Starting Page	2445
Ending Page	2455
Page Count	11
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	39
Issue Number	9
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2011-05-27
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mechanical properties Plastic deformation Permanent deformation Stress softening Plaque Constitutive model Biochemistry Biomedical Engineering Mechanics Biophysics and Biological Physics Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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