NDLI: In Vitro Comparison of Active and Passive Physiological Control Systems for Biventricular Assist Devices

Content Provider	Springer Nature Link
Author	Pauls, Jo P. Stevens, Michael C. Schummy, Emma Tansley, Geoff Fraser, John F. Timms, Daniel Gregory, Shaun D.
Copyright Year	2015
Abstract	The low preload and high afterload sensitivities of rotary ventricular assist devices (VADs) may cause ventricular suction events or venous congestion. This is particularly problematic with rotary biventricular support (BiVAD), where the Starling response is diminished in both ventricles. Therefore, VADs may benefit from physiological control systems to prevent adverse events. This study compares active, passive and combined physiological controllers for rotary BiVAD support with constant speed mode. Systemic (SVR) and pulmonary (PVR) vascular resistance changes and exercise were simulated in a mock circulation loop to evaluate the capacity of each controller to prevent suction and congestion and increase exercise capacity. All controllers prevented suction and congestion at high levels of PVR (900 dynes s cm−5) and SVR (3000 dynes s cm−5), however these events occurred in constant speed mode. The controllers increased preload sensitivity (0.198–0.34 L min−1 mmHg−1) and reduced afterload sensitivity (0.0001–0.008 L min−1 mmHg−1) of the VADs when compared to constant speed mode (0.091 and 0.072 L min−1 mmHg−1 respectively). The active controller increased pump speeds (400–800 rpm) and pump flow by 2.8 L min−1 during exercise, thus increasing exercise capacity. By reducing suction and congestion and by increasing exercise capacity, the control systems presented in this study may help increase quality of life of VAD patients.
Starting Page	1370
Ending Page	1380
Page Count	11
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	44
Issue Number	5
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2015-08-18
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Physiological control Active control Passive control Ventricular assist devices Ventricular suction prevention Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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