NDLI: Validation of Ultrasound Elastography Imaging for Nondestructive Characterization of Stiffer Biomaterials

Content Provider	Springer Nature Link
Author	Zhou, Haoyan Goss, Monika Hernandez, Christopher Mansour, Joseph M. Exner, Agata
Copyright Year	2015
Abstract	Ultrasound elastography (UE) has been widely used as a “digital palpation” tool to characterize tissue mechanical properties in the clinic. UE benefits from the capability of noninvasively generating 2-D elasticity encoded maps. This spatial distribution of elasticity can be especially useful in the in vivo assessment of tissue engineering scaffolds and implantable drug delivery platforms. However, the detection limitations have not been fully characterized and thus its true potential has not been completely discovered. Characterization studies have focused primarily on the range of moduli corresponding to soft tissues, 20–600 kPa. However, polymeric biomaterials used in biomedical applications such as tissue scaffolds, stents, and implantable drug delivery devices can be much stiffer. In order to explore UE’s potential to assess mechanical properties of biomaterials in a broader range of applications, this work investigated the detection limit of UE strain imaging beyond soft tissue range. To determine the detection limit, measurements using standard mechanical testing and UE on the same polydimethylsiloxane samples were compared and statistically evaluated. The broadest detection range found based on the current optimized setup is between 47 kPa and 4 MPa which exceeds the modulus of normal soft tissue suggesting the possibility of using this technique for stiffer materials’ mechanical characterization. The detectable difference was found to be as low as 157 kPa depending on sample stiffness and experimental setup.
Starting Page	1515
Ending Page	1523
Page Count	9
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	44
Issue Number	5
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2015-09-14
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ultrasound elastography Mechanical Biomaterial characterization Nondestructive Noninvasive Elasticity Biomedicine general Biomedical Engineering Biophysics and Biological Physics Mechanics Biochemistry
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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