NDLI: Airflow and Nanoparticle Deposition in a 16-Generation Tracheobronchial Airway Model

Content Provider	Springer Nature Link
Author	Zhang, Zhe Kleinstreuer, Clement Kim, Chong S.
Copyright Year	2008
Abstract	In order to achieve both manageable simulation and local accuracy of airflow and nanoparticle deposition in a representative human tracheobronchial (TB) region, the complex airway network was decomposed into adjustable triple-bifurcation units, spreading axially and laterally. Given Q in = 15 and 30 L/min and a realistic inlet velocity profile, the experimentally validated computer simulation model provided some interesting 3-D airflow patterns, i.e., for each TB-unit they depend on the upstream condition, local geometry and local Reynolds number. Directly coupled to the local airflow fields are the convective-diffusive transport and deposition of nanoparticles, i.e., 1 nm ≤ d p ≤ 100 nm. The CFD modeling predictions were compared to experimental observations as well as analytical modeling results. The CFD-simulated TB deposition values agree astonishingly well with analytical modeling results. However, measurable differences can be observed for bifurcation-by-bifurcation deposition fractions obtained with these two different approaches due to the effects of more realistic inlet conditions and geometric features incorporated in the CFD model. Specifically, while the difference between the total TB deposition fraction (DF) is less than 16%, it may be up to 70% for bifurcation-by-bifurcation DFs. In addition, it was found that fully developed flow and uniform nanoparticle concentrations can be assumed beyond generation G12. For nanoparticles with d p > 10 nm, the geometric effects, including daughter-branch rotation, are minor. Furthermore, the deposition efficiencies at each individual bifurcation in the TB region can be well correlated as a function of an effective diffusion parameter.
Starting Page	2095
Ending Page	2110
Page Count	16
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	36
Issue Number	12
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2008-10-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human tracheobronchial region Computational analysis Airflow Nanoparticle deposition Deposition efficiencies Deposition correlations Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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