NDLI: A Mathematical Model of Human Respiration at Altitude

Content Provider	Springer Nature Link
Author	Wolf, Matthew Bernard Garner, Robert P.
Copyright Year	2007
Abstract	We developed a mathematical model of human respiration in the awake state that can be used to predict changes in ventilation, blood gases, and other critical variables during conditions of hypocapnia, hypercapnia and these conditions combined with hypoxia. Hence, the model is capable of describing ventilation changes due to the hypocapnic-hypoxia of high altitude. The basic model is that of Grodins et al. [Grodins, F. S., J. Buell, and A. J. Bart. J. Appl. Physiol. 22:260–276, 1967]. We updated the descriptions of (1) the effects of blood gases on cardiac output and cerebral blood flow, (2) acid–base balance in blood and tissues, (3) O2 and CO2 binding to hemoglobin and most importantly, (4) the respiratory-chemostat controller. The controller consists of central and peripheral sections. The central chemoceptor-induced ventilation response is simply a linear function of brain $$P_{\rm CO_2}$$ above a threshold value. The peripheral response has both a linear term similar to that for the central chemoceptors, but dependent upon carotid body $$P_{\rm CO_2}$$ and with a different threshold and a complex, nonlinear term that includes multiplication of separate terms involving carotid body $$P_{\rm O_2}$$ and $$P_{\rm CO_2}.$$ Together, these terms produce ‘dogleg’-shaped curves of ventilation plotted against $$P_{\rm CO_2}$$ which form a fan-like family for different values of $$P_{\rm CO_2}.$$ With this chemical controller, our model closely describes a wide range of experimental data under conditions of solely changes in $$P_{\rm CO_2}$$ and for short-term hypoxia coupled with $$P_{\rm CO_2}$$ changes. This model can be used to accurately describe changes in ventilation and respiratory gases during ascent and during short-term residence at altitude. Hence, it has great applicability to studying O2-delivery systems in aircraft.
Starting Page	2003
Ending Page	2022
Page Count	20
File Format	PDF
ISSN	00906964
Journal	Annals of Biomedical Engineering
Volume Number	35
Issue Number	11
e-ISSN	15739686
Language	English
Publisher	Springer US
Publisher Date	2007-08-03
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mathematical model Human respiration Hypercapnia Hypocapnia Hypoxia Altitude hypoxia Biochemistry Mechanics Biophysics/Biomedical Physics Biomedical Engineering Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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