NDLI: Geometry design of herringbone structures for cancer cell capture in a microfluidic device

Content Provider	Springer Nature Link
Author	Wang, Shunqiang Sohrabi, Salman Xu, Jiang Yang, Jie Liu, Yaling
Copyright Year	2016
Abstract	Cancer cell detection with high capture efficiency is important for its extensive clinical applications. Herringbone structures in microfluidic devices have been widely adopted to increase the cell capture performance due to its chaotic effect. Given the fact of laminar flow in microfluidic devices, geometry-based optimization acting as a design strategy is effective and can help researchers reduce repetitive trial experiments. In this work, we presented a computational model to track the cell motion and used normalized capture efficiency to evaluate the tumor cell capture performance under various geometry settings. Cell adhesion probability was implemented in the model to consider the nature of ligand–receptor formation and breakage during cell–surface interactions. A facile approach was introduced to determine the two lumped coefficients of cell adhesion probability through two microfluidic experiments. A comprehensive geometric study was then performed by using this model, and results were explained from the fluid dynamics. Although most of the geometric guides agree with the general criterion concluded in the literature, we found herringbone structures with symmetric arms rather than a short arm–long arm ratio of 1/3 are optimal. This difference mainly comes from the fact that our model considers the particulate nature of cells while most studies in the literature optimize the geometry merely relying on mixing effects. Thus, our computational model implemented with cell adhesion probability can serve as a more accurate and reliable approach to optimize microfluidic devices for cancer cell capture.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	20
Issue Number	11
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-10-18
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell capture Mixing Modeling Geometry design Microfluidics Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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