NDLI: Numerical study on the cell motility interacting with the chemical flow in microchannels

Content Provider	Springer Nature Link
Author	Li, Peiye Du, Xiaohui Hu, Yandong Zhao, Shexu
Copyright Year	2017
Abstract	Beneficial to the steady control of flow properties and concentration gradient profiles, quantification of cell chemotaxis based on microfluidic devices could achieve on the scale of a single cell. However, normal experimental studies assumed that the concentration field was not affected by the existing cell or by the impact of the cell motion. The present paper systematically simulated the interactions of the cell translational and rotational movements with its chemical gradient flow by both 2D and 3D models. The influences of the chemical flow Peclet number, cell’s translational velocity, cell’s rotational velocity and direction on the sensed chemical gradient were investigated. Results showed that both the cell’s translational and rotational movements disturbed its surrounding chemical distribution and affect chemotactic speed and direction later on. Rotating cell brings in flow circulation with it, and consequently the sensed chemical gradient dramatically deviates from the original direction. The cell’s two contrary rotational directions lead to contrary results. 2D model with circular cell is practically feasible due to simplicity, while 3D model with spherical cell is closer to reality. Numerical comparison showed that the 2D model can be used to analyze the cell’s chemotactic tendency, but it also amplifies the cell’s perturbation and then separation to its surrounding chemical flow. Finally, a single cell’s interactive chemotaxis in a micro chamber was simulated based on experimental measured chemotactic coefficient. The interactive chemotactic cell kept moving slightly upstream instead of upright crossing the interface. This work may contribute to the development of chemotactic measurement method and precise evaluation on the cell’s chemotactic sensitivity.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	21
Issue Number	4
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2017-03-18
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell chemotaxis Cell chemokinetics Numerical simulation Concentration gradient Cell movement Chemical microenvironment Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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