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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sancho, J.V. Cabanes, R.A. López, F.J. Hernández, F. |
| Copyright Year | 2003 |
| Abstract | A rapid and automated method based on coupled-column liquid chromatography (LC-LC) with fluorescence detection has been developed for the determination of 1-naphtol in human urine. Urine samples were hydrolyzed with sulfatase and a 100 μL aliquot was directly injected in the LC-LC system, using as first separation column a Kromasil C18 10 μm 30 × 4 mm. The fraction containing the analyte was transferred on-line to the second analytical column ABZ+ 5 μm 150 × 4 mm, which was connected to the fluorescence detector. The clean-up performed by the coupled-column system gave the necessary selectivity and avoids additional clean-up steps. The method was linear in the range 10–500 ng mL−1 (correlation coefficient of 0.9999). Accuracy and precision were evaluated by means of recovery experiments from different fortified urine samples (25 and 250 ng mL−1), obtaining coefficients of variation lower than 5% and recoveries between 91 and 102% in all cases. The method proposed allows the determination of 1-naphthol at a concentration level as low as 10 ng mL−1, without any preconcentration step. The applicability of the proposed method has been confirmed by analyzing different urine samples from a farmer exposed to carbaryl. Concentrations of 1-naphthol, the main metabolite of carbaryl, between 60 and 80 ng mL−1 were found in urine samples obtained during the application period of carbaryl in the field. 72 h after finishing the application, 1-naphtol was not detected in urine. |
| Starting Page | 565 |
| Ending Page | 569 |
| Page Count | 5 |
| File Format | |
| ISSN | 00095893 |
| Journal | Chromatographia |
| Volume Number | 58 |
| Issue Number | 9-10 |
| e-ISSN | 16121112 |
| Language | English |
| Publisher | Vieweg Verlag |
| Publisher Date | 2003-01-01 |
| Publisher Place | Wiesbaden |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Column liquid chromatography Coupled columns Fluorescence detection 1-Naphthol in urine Carbaryl exposure |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry |
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