NDLI: Determination of Ziprasidone by UPLC-MS-MS and Its Application to a Pharmacokinetic Study of Chinese Schizophrenics

Content Provider	Springer Nature Link
Author	Lei, Yan Qing Zhang, Wen Yuan Li, Huan De Yan, Miao Zhu, Rong Hua
Copyright Year	2010
Abstract	A simple, rapid, and selective method to determine the concentration of ziprasidone hydrochloride in schizophrenics’ plasma using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) was developed and validated. The UPLC separation was carried out with an Acquity UPLC BEH C18 column (50 × 2.1 mm i.d., 1.7 μm particle size). The mobile phase consisted of methanol–water (50:50, v/v; the water included 15 mM NH4Ac and 0.125% acetic acid). The detection was performed on a triple-quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI) at m/z 412.82 → 193.75 for ziprasidone and m/z 236.87 → 193.76 for the internal standard, carbamazepine. Solid-phase extraction was used to extract ziprasidone hydrochloride and carbamazepine from plasma. Ziprasidone and the internal standard eluted as sharp, symmetrical peaks with retention times of 1.24 ± 0.01 min and 1.74 ± 0.02 min, respectively. Calibration curves of ziprasidone at concentrations ranging from 0.7 to 400 ng mL−1 exhibited excellent linearity (r = 0.9995), with a lower limit of quantification of 0.7 ng mL−1. Intra- and inter-day relative standard deviations were less than 7.75% RSD and 5.43% RSD, respectively. The extraction recovery was above 81.3%. The described assay method showed acceptable precision, accuracy, linearity, stability, and specificity and can be used for pharmacokinetic studies.
Starting Page	975
Ending Page	979
Page Count	5
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	72
Issue Number	9-10
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2010-08-22
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Column liquid chromatography-mass spectrometry Ziprasidone Pharmacokinetics Schizophrenics Measurement Science and Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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