NDLI: Practicality of Tetragonal Nano-Zirconia as a Prospective Sorbent in the Preparation of 99Mo/99mTc Generator for Biomedical Applications

Content Provider	Springer Nature Link
Author	Chakravarty, Rubel Shukla, Rakesh Ram, Ramu Tyagi, Avesh Kumar Dash, Ashutosh Venkatesh, Meera
Copyright Year	2010
Abstract	The feasibility of using tetragonal nano-zirconia (t-ZrO2) as an effective sorbent for developing a 99Mo/99mTc chromatographic generator was demonstrated. The structural characteristics of the sorbent matrix were investigated by different analytical techniques such as XRD, BET surface area analysis, FT-IR, TEM etc. The material synthesized was nanocrystalline, in tetragonal phase with an average particle size of ~7 nm and a large surface area of 340 m2 g−1. The equilibrium sorption capacity of t-ZrO2 is >250 mg Mo g−1. The present study indicates that 99Mo is both strongly and selectively retained by t-ZrO2 at acidic pH and 99mTc could be readily eluted from it, using 0.9% NaCl solution. A 9.25 GBq (250 mCi) t-ZrO2 based chromatographic 99Mo/99mTc generator was developed and its performance was repeatedly evaluated for 10 days. 99mTc could be eluted with >85% yield having acceptable radionuclidic, radiochemical and chemical purity for clinical applications. The compatibility of the product in the preparation of 99mTc labeled formulations such as 99mTc-EC and 99mTc-DMSA was evaluated and found to be satisfactory.
Starting Page	875
Ending Page	884
Page Count	10
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	72
Issue Number	9-10
e-ISSN	16121112
Language	English
Publisher	Vieweg Verlag
Publisher Date	2010-09-26
Publisher Place	Wiesbaden
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chromatographic 99Mo/99mTc generator Sorption capacity Distribution ratio Zeta potential Nano-zirconia Measurement Science and Instrumentation Plant Sciences Biochemistry Pharmacy Organic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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