NDLI: Multivariate Optimization and Validation of a CZE Method for the Analysis of Pridinol Mesylate and Meloxicam in Tablets

Content Provider	Springer Nature Link
Author	Vignaduzzo, Silvana E. Vera Candioti, Luciana Castella, Patricia M. Goicoechea, Héctor C. Kaufman, Teodoro S.
Copyright Year	2011
Abstract	A capillary zone electrophoresis method for the simultaneous determination of pridinol mesylate (PRI) and meloxicam (MEL) employing epinastine hydrochloride and piroxicam as internal standards, was developed and optimized employing experimental design and response surface methodologies. The separation was optimally achieved in less than 2 min at 30 kV in an uncoated fused-silica capillary (41.4 cm × 75 μm I.D.), employing an 18 mmol L−1 sodium phosphate buffer solution (pH 5.90) at 25 °C. Samples were injected in hydrodynamic mode (50 mbar, 5 s) and the analytes were spectrophotometrically detected at 200 nm. Method robustness was demonstrated by ANOVA of determinations performed under conditions slightly different from the optimum. The method was validated regarding separation selectivity (peak purity factors > 0.99), linearity and range (PRI = 17.6–31.4 mg L−1; MEL = 66.5–122.5 mg L−1), accuracy (PRI = 100.2–101.9%; MEL = 98.9–100.7%) and precision. The RSD values obtained were ≤1.3% for injection repeatability and ≤1.9% for intra-day precision. The limits of detection (1.0 and 0.9 mg L−1) and quantification (3.3 and 16.5 mg L−1) of PRI and MEL, respectively, were also determined. The method was successfully applied to the determination of both drugs in three brands of tablet formulations. No statistically significant differences were observed when these results were compared with those of a RP-HPLC method.
Starting Page	609
Ending Page	617
Page Count	9
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	74
Issue Number	7-8
e-ISSN	16121112
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-07-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Capillary zone electrophoresis Experimental designs Meloxicam Pridinol Pharmacy Organic Chemistry Proteomics Analytical Chemistry Plant Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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