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Archives of Virology : Volume 143

Archives of Virology : Volume 142

Active HIV-1 redistribution and replication in the brain with HIV encephalitis

Content Provider	Springer Nature Link
Author	Gatanaga, H. Oka, S. Ida, S. Wakabayashi, T. Shioda, T. Iwamoto, A.
Copyright Year	1999
Abstract	The central nervous system (CNS) is of particular importance in human immunodeficiency virus type 1 (HIV-1) infection. First, the CNS may be difficult to access for anti-retroviral treatment and may become a sanctuary for residual viruses. Second, HIV-1 infection may lead to AIDS dementia complex (ADC) culminating in HIV-1 encephalitis. In order to examine the pattern of drug resistance and the role of encephalitis in enhancing viral redistribution to the CNS, we compared pol gene quasispecies of the spleen and brain in two patients with and two patients without HIV-1 encephalitis, who had been treated with zidovudine (AZT). Although a variable degree of AZT resistance was noted in both the spleen and brain of all patients, phylogenetic analysis indicated that quasispecies developed rather independently in the systemic circulation (spleen) and CNS (brain) of patients without HIV-1 encephalitis, while similar pol gene sequences were obtained from the two compartments of patients with HIV-1 encephalitis. env gene V3 region of patients with HIV-1 encephalitis showed distinct quasispecies in the spleen and brain. Our results suggest that HIV-1 redistribution to CNS is more active in cases with encephalitis and that HIV-1 distributed late to CNS grow actively under certain selective pressure exerted on the V3 region of the env gene.
Starting Page	29
Ending Page	43
Page Count	15
File Format	PDF
ISSN	03048608
Journal	Archives of Virology
Volume Number	144
Issue Number	1
e-ISSN	14328798
Language	English
Publisher	Springer-Verlag
Publisher Date	2014-04-08
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Virology Medical Microbiology Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Virology Medicine

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