NDLI: A microfluidic chip based on an ITO support modified with Ag-Au nanocomposites for SERS based determination of melamine

Content Provider	Springer Nature Link
Author	Wang, Rong Xu, Yi Wang, Renjie Wang, Chunyan Zhao, Huazhou Zheng, Xiangquan Liao, Xing Cheng, Li
Copyright Year	2016
Abstract	This article describes a microfluidic SERS chip-based rapid and high-throughput method for the determination of chemical and biological analytes, specifically of melamine. The chip consists of an indium tin oxide (ITO) glass plate modified with silver-gold nanocomposites (Ag-Au NCs) and a polydimethylsiloxane (PDMS) cover plate. The chip has five parallel microfluidic channels. The ITO glass provides electrical conductivity and has a smooth surface which makes it well suited for the deposition of the Ag-Au NC by electrodeposition and galvanic replacement. This technique allows good control of the morphology and composition of the composite. Under optimized conditions, the microfluidic SERS chip provides excellent sensitivity for 4-mercaptobenzoic acid (4-MBA). The detection limit is 0.1 nM and the SERS enhancement factor is 2.7×1010. The chip exhibits good stability over time and good reproducibility, with a RSD of 8.6 % between the 5 micro-channels. The chip was successfully applied to the determination of melamine in milk with a 10 nM detection limit and an analytical range from 10 nM to 0.1 mM. It is demonstrated that the microfluidic SERS chip developed here shows great promise for use in biochemical assays. Graphical abstract A microfluidic SERS chip employing gold nanocomposites (Ag-Au NCs) as SERS-active substrate was fabricated. Its SERS enhancement factor is 2.7⋅1010. The chip was applied to determinate melamine in milk with detection limit of 10 nM.
Starting Page	279
Ending Page	287
Page Count	9
File Format	PDF
ISSN	00263672
Journal	Microchimica Acta
Volume Number	184
Issue Number	1
e-ISSN	14365073
Language	English
Publisher	Springer Vienna
Publisher Date	2016-11-18
Publisher Place	Vienna
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Silver-gold nanomaterial PDMS SERS substrate Milk analysis Electrodeposition Galvanic replacement Nanochemistry Nanotechnology Characterization and Evaluation of Materials Analytical Chemistry Microengineering
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Flower-like gold nanostructures electrodeposited on indium tin oxide (ITO) glass as a SERS-active substrate for sensing dopamine

PDMS-Au/Ag Nanocomposite Films as Highly Sensitive SERS Substrates

Enhancement of the chemiluminescence of permanganate-formaldehyde system by gold/silver nanoalloys and its application to trace determination of melamine

Visual test for melamine using silver nanoparticles modified with chromotropic acid

Colorimetric determination of neomycin using melamine modified gold nanoparticles

Silver–gold core-shell nanoparticles containing methylene blue as SERS labels for probing and imaging of live cells

Rapid determination of melamine in milk and milk powder by surface-enhanced Raman spectroscopy and using cyclodextrin-decorated silver nanoparticles

Synthesis of p-aminothiophenol-embedded gold/silver core-shell nanostructures as novel SERS tags for biosensing applications

Facile synthesis of a porous network-like silver film for electrocatalytic detection of nitrate

A microfluidic chip based on an ITO support modified with Ag-Au nanocomposites for SERS based determination of melamine

Similar Documents

Flower-like gold nanostructures electrodeposited on indium tin oxide (ITO) glass as a SERS-active substrate for sensing dopamine

PDMS-Au/Ag Nanocomposite Films as Highly Sensitive SERS Substrates

Enhancement of the chemiluminescence of permanganate-formaldehyde system by gold/silver nanoalloys and its application to trace determination of melamine

Visual test for melamine using silver nanoparticles modified with chromotropic acid

Colorimetric determination of neomycin using melamine modified gold nanoparticles

Silver–gold core-shell nanoparticles containing methylene blue as SERS labels for probing and imaging of live cells

Rapid determination of melamine in milk and milk powder by surface-enhanced Raman spectroscopy and using cyclodextrin-decorated silver nanoparticles

Synthesis of p-aminothiophenol-embedded gold/silver core-shell nanostructures as novel SERS tags for biosensing applications

Facile synthesis of a porous network-like silver film for electrocatalytic detection of nitrate

A microfluidic chip based on an ITO support modified with Ag-Au nanocomposites for SERS based determination of melamine