NDLI: Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection

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Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection

Content Provider	Springer Nature Link
Author	Podlech, Jürgen Ebert, Stefan Becker, Marc Reddehase, Matthias J. Stassen, Michael Lemmermann, Niels A. W.
Copyright Year	2015
Abstract	Reactivation of latent cytomegalovirus (CMV) in the transient immunocompromised state after hematoablative treatment is a major concern in patients undergoing hematopoietic cell transplantation (HCT) as a therapy of hematopoietic malignancies. Timely reconstitution of antiviral CD8 T cells and their efficient recruitment to the lungs is crucial for preventing interstitial pneumonia, the most severe disease manifestation of CMV in HCT recipients. Here, we review recent work in a murine model, implicating mast cells (MC) in the control of pulmonary infection. Murine CMV (mCMV) productively infects MC in vivo and triggers their degranulation, resulting in the release of the CC chemokine ligand 5 (CCL5) that attracts CD8 T cells to infiltrate infected tissues. Comparing infection of MC-sufficient C57BL/6 mice and congenic MC-deficient Kit W-sh/W-sh “sash” mutants revealed an inverse relation between the number of lung-infiltrating CD8 T cells and viral burden in the lungs. Specifically, reduced lung infiltration by CD8 T cells in “sash” mutants was associated with an impaired infection control. The causal, though indirect, involvement of MC in antiviral control was confirmed by reversion of the deficiency phenotype in “sash” mutants reconstituted with MC. These recent findings predict that efficient MC reconstitution facilitates the control of CMV infection also in immunocompromised HCT recipients.
Starting Page	327
Ending Page	334
Page Count	8
File Format	PDF
ISSN	03008584
Journal	Medical Microbiology and Immunology
Volume Number	204
Issue Number	3
e-ISSN	14321831
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-02-04
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CCL5 Chemokine Immune surveillance Mast cell Mast cell-specific Cre recombination Protective immunity Medical Microbiology Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Microbiology (medical)

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Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection

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Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection