NDLI: Sepsis and cytomegalovirus: foes or conspirators?

Content Provider	Springer Nature Link
Author	Mansfield, Sara Grießl, Marion Gutknecht, Michael Cook, Charles H.
Copyright Year	2015
Abstract	Cytomegalovirus (CMV) reactivation in non-immune-suppressed critically ill patients is an area of increasing interest. CMV has long been appreciated as a pathogen in immunocompromised hosts. CMV reactivates in approximately one-third of latently infected non-immune-suppressed hosts during critical illness; however, its role as a pathogen in these patients remains unclear. CMV reactivation has been linked to bacterial sepsis and likely results from inflammation, transient immune compromise, and viral epigenetic changes. While CMV may improve immune response to some bacterial infections, other data suggest that CMV induces exaggerated responses to severe infections that may be harmful to latently infected hosts. These results also suggest that previous infection history may explain significant differences seen between human septic responses and murine models of sepsis. While critically ill human hosts clearly have worse outcomes associated with CMV reactivation, determining causality remains an area of investigation, with randomized control trials currently being performed. Here we review the current literature and highlight areas for future investigation.
Starting Page	431
Ending Page	437
Page Count	7
File Format	PDF
ISSN	03008584
Journal	Medical Microbiology and Immunology
Volume Number	204
Issue Number	3
e-ISSN	14321831
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-03-19
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cytomegalovirus Sepsis Reactivation Medical Microbiology Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Microbiology (medical)

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