NDLI: H+ ion modulation of C-type inactivation of Shaker K+ channels

Content Provider	Springer Nature Link
Author	Pérez Cornejo, Patricia
Copyright Year	1999
Abstract	The participation of an extracellular loop in C-type inactivation of voltage-gated K+ channels was investigated. A wild-type phenylalanine (at position 425) between the fifth putative transmembrane segment (S5) and the pore region of the Shaker K+ channel was mutated to a histidine and the functional consequences of protonating the imidizole group of the histidine were examined. C-type inactivation of both wild-type and mutant channels was sensitive to external pH over the range of 5.2–8. The pH dependence of wild-type channels was characterized by an apparent pK value of 5.0. The inactivation kinetics of F425H mutant channels had a pH dependence with a pK of 5.8 – in addition to the pH dependence of the wild-type channels. Moreover, at pH 7 and 8 the voltage dependence of C-type inactivation kinetics was manifest only in the F425H mutant channels. C-type inactivation in wild-type channels involves a chemical group with a low pK. Taken together, these results suggest that residues located in the extracellular S5-pore loop of the Shaker K+ channel participate in C-type inactivation.
Starting Page	865
Ending Page	870
Page Count	6
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	437
Issue Number	6
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-04-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

K+-dependent stability and ion conduction of Shab K+ channels: a comparison with Shaker channels

Mechanisms of the inhibition of Shaker potassium channels by protons

Gating of the shaker potassium channel is modulated differentially by N-glycosylation and sialic acids

ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K+ o-dependent resting inactivation

Glibenclamide suppresses stretch-activated ANP secretion: involvements of K+ ATP channels and L-type Ca2+ channel modulation

Temperature and pressure dependence of Shaker K+ channel N- and C-type inactivation

A link between fertility and K+ homeostasis: role of the renal H,K-ATPase type 2

Phosphoinositide-mediated gating of inwardly rectifying K+ channels

Effect of the inactivating "ball" peptide of Shaker B on intermediate conductance Ca2+-dependent inwardly rectifying K+ channels of HeLa cells

H+ ion modulation of C-type inactivation of Shaker K+ channels

Similar Documents

K+-dependent stability and ion conduction of Shab K+ channels: a comparison with Shaker channels

Mechanisms of the inhibition of Shaker potassium channels by protons

Gating of the shaker potassium channel is modulated differentially by N-glycosylation and sialic acids

ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K+ o-dependent resting inactivation

Glibenclamide suppresses stretch-activated ANP secretion: involvements of K+ ATP channels and L-type Ca2+ channel modulation

Temperature and pressure dependence of Shaker K+ channel N- and C-type inactivation

A link between fertility and K+ homeostasis: role of the renal H,K-ATPase type 2

Phosphoinositide-mediated gating of inwardly rectifying K+ channels

Effect of the inactivating "ball" peptide of Shaker B on intermediate conductance Ca2+-dependent inwardly rectifying K+ channels of HeLa cells

H+ ion modulation of C-type inactivation of Shaker K+ channels