NDLI: Hypertonic saline inhibits luminal sodium channels in respiratory epithelium

Content Provider	Springer Nature Link
Author	Hebestreit, Alexandra Kersting, Ulrich Hebestreit, Helge
Copyright Year	2007
Abstract	Physical exercise with increased ventilation leads to a considerable rise in water loss from the airways. The mechanisms underlying the regulation of transepithelial fluid transport necessary to compensate for these losses are unknown but may include changes in luminal ion channel conductance. The present study was designed to examine the effects of an increase in luminal chloride and sodium concentrations which may locally occur during hyperventilation on luminal ion conductance in the respiratory epithelium of healthy controls and patients diagnosed with cystic fibrosis (CF). Changes in luminal chloride and sodium conductance were inferred by recording nasal potential difference in eight healthy subjects and 10 patients with CF, using superfusing solutions based on isotonic saline (150 mM) on one occasion and solutions based on hypertonic saline (300 mM) on the other. Switching from isotonic to hypertonic saline superfusion decreased potential difference in controls and CF patients significantly. Amiloride induced a decrease of potential difference which was larger with isotonic than with hypertonic saline (controls 9.5 ± 6.1 vs. 3.7 ± 4.6 mV; CF 17.2 ± 7.2 vs. 9.8 ± 7.6 mV). Chloride conductance stimulated with solutions low in chloride and containing isoproterenol was not significantly changed by hypertonic saline solutions compared with isotonic solutions in both groups. The findings indicate a significant inhibition of luminal sodium conductance by high luminal sodium concentrations. This mechanism may be involved in the regulation of fluid transport across the respiratory epithelium during exercise and in the improvement of mucociliary clearance and lung functions with inhalation of hypertonic saline in CF.
Starting Page	177
Ending Page	183
Page Count	7
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	100
Issue Number	2
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-02-23
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nasal potential difference ENaC Cystic fibrosis Exercise Hypertonic saline Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis

Insight into motor adaptation to pain from between-leg compensation

Mechanisms of activity-related breathlessness in healthy human pregnancy

Sweat sodium concentration during exercise in the heat in aerobically trained and untrained humans

Upregulated expression of ENaC in human CF nasal epithelium.

Cardiac function and arteriovenous oxygen difference during exercise in obese adults

Respiratory muscle training improves swimming endurance in divers

Expiratory muscle fatigue impairs exercise performance

Influence of exercise on airway epithelia in cystic fibrosis: a review.

Hypertonic saline inhibits luminal sodium channels in respiratory epithelium

Similar Documents

Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis

Insight into motor adaptation to pain from between-leg compensation

Mechanisms of activity-related breathlessness in healthy human pregnancy

Sweat sodium concentration during exercise in the heat in aerobically trained and untrained humans

Upregulated expression of ENaC in human CF nasal epithelium.

Cardiac function and arteriovenous oxygen difference during exercise in obese adults

Respiratory muscle training improves swimming endurance in divers

Expiratory muscle fatigue impairs exercise performance

Influence of exercise on airway epithelia in cystic fibrosis: a review.

Hypertonic saline inhibits luminal sodium channels in respiratory epithelium