NDLI: Normo or hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnesses

Content Provider	Springer Nature Link
Author	Savourey, Gustave Launay, Jean Claude Besnard, Yves Guinet Lebreton, Angélique Alonso, Antonia Sauvet, Fabien Bourrilhon, Cyprien
Copyright Year	2007
Abstract	Assessment of individual susceptibility to altitude illnesses and more particularly to acute mountain sickness (AMS) by means of tests performed in normobaric hypoxia (NH) or in hypobaric hypoxia (HH) is still debated. Eighteen subjects were submitted to HH and NH tests (PIO2=120 hPa, 30 min) before an expedition. Maximal and mean acute mountain sickness scores (AMSmax and mean) were determined using the self-report Lake Louise questionnaire scored daily. Cardio-ventilatory (f, VT, PetO2 and PetCO2, HR and finger pulse oxymetry SpO2) were measured at times 5 and 30 min of the tests. Arterial (PaO2, PaCO2, pH, SaO2) and capillary haemoglobin (Hb) measurements were performed at times 30 min. Hypoxic ventilatory (HVR) and cardiac (HCR) responses, peripheral O2 blood content (CpO2) were calculated. A significant time effect is found for ΔSpO2 (P = 0.04). Lower PaCO2 (P = 0.005), SaO2 (P = 0.07) and higher pH (P = 0.02) are observed in HH compared to NH. AMSmax varied from 3 to12 and AMSmean between 0.6 and 3.5. In NH at 30 min, AMSmax is related to PetO2 (R = 0.61, P = 0.03), CpO2 (R = −0.53, P = 0.02) and in HH to CpO2 (R = −0.57, P = 0.01). In NH, AMSmean is related to Δf (R = 0.46, P = 0.05), HCR (R = 0.49, P = 0.04), CpO2 (R = −0.51, P = 0.03) and, in HH at 30 min, to VT (R = 0.69, P = 0.01) and a tendency for CpO2 (R = −0.43, P = 0.07). We conclude that HH and NH tests are physiologically different and they must last 30 min. CpO2 is an important variable to predict AMS. For practical considerations, NH test is proposed to quantify AMS individual susceptibility using the formulas: AMSmax = 9.47 + 0.104PetO2(hPa)–0.68CpO2 (%), (R = 0.77, P = 0.001); and AMSmean = 3.91 + 0.059Δf + 0.438HCR–0.135CpO2 (R = 0.71, P = 0.017).
Starting Page	193
Ending Page	205
Page Count	13
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	100
Issue Number	2
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-02-24
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hypoxic tests Hypoxia Acute mountain sickness Altitude illnesses Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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