NDLI: Lung function is unchanged in the 1 G environment following 6-months exposure to microgravity

Content Provider	Springer Nature Link
Author	Prisk, G. Kim Fine, Janelle M. Cooper, Trevor K. West, John B.
Copyright Year	2008
Abstract	Many organ systems adapt in response to the removal of gravity, such as that occurring during spaceflight. Such adaptation occurs over varying time periods depending on the organ system being considered, but the effect is that upon a return to the normal 1 G environment, the organ system is ill-adapted to that environment. As a consequence, either countermeasures to the adaptive process in flight, or rehabilitation upon return to 1 G is required. To determine whether the lung changed in response to a long period without gravity, we studied numerous aspects of lung function on ten subjects (one female) before and after they were exposed to 4–6 months of microgravity (μG, weightlessness) in the normobaric normoxic environment of the International Space Station. With the exception of small (and likely physiologically inconsequential) changes in expiratory reserve volume, one index of peripheral gas mixing in the periphery of the lung, and a possible slight reduction in DLCO in the early postflight period despite an unchanged cardiac output, lung function was unaltered by 4–6 months in μG. These results suggest that unlike many other organ systems in the human body, lung function returns to normal after long term exposure to the removal of gravity. We conclude that that in a normoxic, normobaric environment, lung function is not a concern following long-duration future spaceflight exploration missions of up to 6 months.
Starting Page	617
Ending Page	623
Page Count	7
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	103
Issue Number	6
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-05-07
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gas mixing Pulmonary function Spaceflight Humans Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ventilation-perfusion inequality in the human lung is not increased following no-decompression-stop hyperbaric exposure

Disuse of the musculo-skeletal system in space and on earth

Effects of 14 days of microgravity on fast hindlimb and diaphragm muscles of the rat

Investigating performance and lung function in a hot, humid and ozone-polluted environment

Physiological responses and manual performance in humans following repeated exposure to severe cold at night

Time-dependent changes in pulmonary vascular responses to acute hypoxia during and after cold exposure in rats

Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD

Influence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans

Two methods for determining plasma IL-6 in humans at rest and following exercise

Lung function is unchanged in the 1 G environment following 6-months exposure to microgravity

Similar Documents

Ventilation-perfusion inequality in the human lung is not increased following no-decompression-stop hyperbaric exposure

Disuse of the musculo-skeletal system in space and on earth

Effects of 14 days of microgravity on fast hindlimb and diaphragm muscles of the rat

Investigating performance and lung function in a hot, humid and ozone-polluted environment

Physiological responses and manual performance in humans following repeated exposure to severe cold at night

Time-dependent changes in pulmonary vascular responses to acute hypoxia during and after cold exposure in rats

Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD

Influence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans

Two methods for determining plasma IL-6 in humans at rest and following exercise

Lung function is unchanged in the 1 G environment following 6-months exposure to microgravity