NDLI: Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity

Content Provider	Springer Nature Link
Author	Darquenne, Chantal Prisk, G. Kim
Copyright Year	2008
Abstract	Lunar dust presents a potential toxic challenge to future explorers of the moon. The extent of the inflammatory response to lunar dust will in part depend on where in the lung particles deposit. To determine the effect of lowered gravity, we measured deposition of 0.5 and 1 μm diameter particles in six subjects on the ground (1G) and during short periods of lunar gravity (1/6G) aboard the NASA Microgravity Research Aircraft. Total deposition was measured during continuous aerosol breathing, and regional deposition by aerosol bolus inhalations at penetration volumes (V p) of 200, 500 and 1,200 ml. For both particle sizes (d p), deposition was gravity-dependent with the lowest deposition occurring at the lower G-level. Total deposition decreased by 25 and 32% from 1G to 1/6G for 0.5 and 1 μm diameter particles, respectively. In the bolus tests, deposition increased with increasing V p. However, the penetration volume required to achieve a given deposition level was larger in 1/6G than in 1G. For example, for d p = 1 μm (0.5 μm), a level of 25% deposition was reached at V p = 260 ml (370 ml) in 1G but not until V p = 730 ml (835 ml) in 1/6G. Thus in 1G, deposition in more central airways reduces the transport of fine particles to the lung periphery. In the fractional gravity environment of a lunar outpost, while inhaled fine particle deposition may be lower than on earth, those particles that are deposited will do so in more peripheral regions of the lung.
Starting Page	687
Ending Page	695
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	103
Issue Number	6
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-05-17
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lunar gravity Aerosol deposition Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cardiovascular autonomic adaptation in lunar and martian gravity during parabolic flight

Is urinary specific gravity a useful simple marker of fluid depletion in athletes?

Closing volume: a reappraisal (1967–2007)

Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity

Muscle fiber conduction velocity is more affected after eccentric than concentric exercise

Pain and changes in peripheral resistance at high vascular transmural pressure in the human forearm

Blood pressure regulation: every adaptation is an integration?

Hypoxia application in athletes is not doping

Physical capacity–match physical performance relationships in soccer: simply, more complex

Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity

Similar Documents

Cardiovascular autonomic adaptation in lunar and martian gravity during parabolic flight

Is urinary specific gravity a useful simple marker of fluid depletion in athletes?

Closing volume: a reappraisal (1967–2007)

Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity

Muscle fiber conduction velocity is more affected after eccentric than concentric exercise

Pain and changes in peripheral resistance at high vascular transmural pressure in the human forearm

Blood pressure regulation: every adaptation is an integration?

Hypoxia application in athletes is not doping

Physical capacity–match physical performance relationships in soccer: simply, more complex

Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity