NDLI: Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia

Content Provider	Springer Nature Link
Author	Fan, Jui Lin Burgess, Keith R. Thomas, Kate N. Peebles, Karen C. Lucas, Samuel J. E. Lucas, Rebekah A. I. Cotter, James D. Ainslie, Philip N.
Copyright Year	2010
Abstract	Indomethacin (INDO) has the potential to be a useful tool to explore the influence of cerebral blood flow and its responses to CO2 on ventilatory control. However, the effect of INDO on the cerebrovascular and ventilatory response to hypoxia remains unclear; therefore, we examined the effect of INDO on ventilatory and cerebrovascular sensitivity to hypoxia and hypercapnia. We measured end-tidal gases, ventilation $$ (\dot{V}_{\text{E}} ), $$ and middle cerebral artery velocity (MCAv) before and 90 min following INDO (100 mg) in 12 healthy participants at rest and during hyperoxic hypercapnia and isocapnic hypoxia. Following INDO, resting $$ \dot{V}_{\text{E}} $$ and end-tidal gases were unaltered (P > 0.05), whilst MCAv was lowered by 25 ± 19% (P < 0.001). INDO ingestion reduced MCAv-CO2 reactivity by 46 ± 29% (2.9 ± 0.9 vs. 1.7 ± 0.9 cm s−1 mmHg−1; P < 0.001) and enhanced the $$ \dot{V}_{\text{E}} $$ -CO2 sensitivity by 0.5 ± 0.5 L min−1 mmHg−1 (1.9 ± 1.5 vs. 2.3 ± 1.6 L min−1 mmHg−1; P < 0.05). No changes were observed in either the MCAv or $$ \dot{V}_{\text{E}} $$ responsiveness to isocapnic hypoxia following INDO ingestion (P > 0.05). These findings indicate that INDO does not alter cerebrovascular and ventilatory responsiveness to hypoxia, indicating a preserved peripheral chemoreflex in response to this pharmacological agent.
Starting Page	601
Ending Page	610
Page Count	10
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	111
Issue Number	4
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-10-12
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Indomethacin Cerebral blood flow Chemoreflex Sports Medicine Human Physiology Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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