NDLI: Pain and changes in peripheral resistance at high vascular transmural pressure in the human forearm

Content Provider	Springer Nature Link
Author	Green, N. D. C. Brown, M. D. Coote, J. H.
Copyright Year	2007
Abstract	A hydrostatic rise in forearm vascular transmural pressure may be associated with an increase in forearm blood flow (FBF) that causes pain. To test this hypothesis, forearm vascular transmural pressure was elevated in eight male volunteers by a series of 1-min hypobaric exposures of the left arm to incrementing differential pressures of 40, 80, 120, 140, 160 and 200 mmHg. The series was repeated after a 30-min interval. Forearm venous pressure (FVP) was measured in the median antecubital vein, and FBF was determined by ultrasound Doppler in the axillary artery. Pain level was recorded by numerical rating scale. In all subjects, an increase in FBF and forearm vascular conductance (FVC) occurred (P < 0.05) at high FVP (mean ± SE, 184 ± 8 mmHg). Pain was linearly related to the increase in FVC. In the second series of exposures, increases in FBF, FVC and pain occurred at a lower transmural pressure (FVP 152 ± 15 mmHg, P < 0.01). It is concluded that intense forearm pain is associated with a failure of autoregulation in the peripheral vascular bed and is worsened on repeated exposure to high transmural pressure. This may explain the overt forearm pain experienced by the crews of high performance military aircraft during manoeuvring.
Starting Page	627
Ending Page	635
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	100
Issue Number	6
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-05-03
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gravity Forearm vascular conductance Forearm blood flow Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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