NDLI: Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study

Content Provider	Springer Nature Link
Author	Bakshi, Mayur V. Barjaktarovic, Zarko Azimzadeh, Omid Kempf, Stefan J. Merl, Juliane Hauck, Stefanie M. Eriksson, Per Buratovic, Sonja Atkinson, Michael J. Tapio, Soile
Copyright Year	2013
Abstract	Epidemiological studies establish that children and young adults are especially susceptible to radiation-induced cardiovascular disease (CVD). The biological mechanisms behind the elevated CVD risk following exposure at young age remain unknown. The present study aims to elucidate the long-term effects of ionizing radiation by studying the murine cardiac proteome after exposure to low and moderate radiation doses. NMRI mice received single doses of total body 60Co gamma-irradiation on postnatal day 10 and were sacrificed 7 months later. Changes in cardiac protein expression were quantified using isotope-coded protein label and tandem mass spectrometry. We identified 32, 31, 66, and 34 significantly deregulated proteins after doses of 0.02, 0.1, 0.5, and 1.0 Gy, respectively. The four doses shared 9 deregulated proteins. Bioinformatics analysis showed that most of the deregulated proteins belonged to a limited set of biological categories, including metabolic processes, inflammatory response, and cytoskeletal structure. The transcription factor peroxisome proliferator-activated receptor alpha was predicted as a common upstream regulator of several deregulated proteins. This study indicates that both adaptive and maladaptive responses to the initial radiation damage persist well into adulthood. It will contribute to the understanding of the long-term consequences of radiation-induced injury and developmental alterations in the neonatal heart.
Starting Page	451
Ending Page	461
Page Count	11
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	52
Issue Number	4
e-ISSN	14322099
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-07-24
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Low-dose ionizing radiation Acute exposure Total body irradiation Cardiac effects Fibrinogen PPAR alpha Proteomics ICPL Biophysics and Biological Physics Effects of Radiation/Radiation Protection Environmental Physics Environmental Monitoring/Analysis Ecosystems
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A mouse model of cytogenetic analysis to evaluate caesium137 radiation dose exposure and contamination level in lymphocytes

Modelling the effects of ionizing radiation on survival of animal population: acute versus chronic exposure

Effects of chronic low-dose exposure to ionizing radiation on physician microvascular structure revealed by nail fold capillaroscopy

Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation

Cardiovascular effects after low-dose exposure and radiotherapy: what research is needed?

Occupational exposure to low doses of ionizing radiation and cataract development: a systematic literature review and perspectives on future studies

Maternal occupational exposure to ionizing radiation and birth defects

Modification of radiation-induced oral mucositis (mouse) by adult stem cell therapy: single-dose irradiation

Dose and dose-rate effects of ionizing radiation: a discussion in the light of radiological protection

Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study

Similar Documents

A mouse model of cytogenetic analysis to evaluate caesium137 radiation dose exposure and contamination level in lymphocytes

Modelling the effects of ionizing radiation on survival of animal population: acute versus chronic exposure

Effects of chronic low-dose exposure to ionizing radiation on physician microvascular structure revealed by nail fold capillaroscopy

Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation

Cardiovascular effects after low-dose exposure and radiotherapy: what research is needed?

Occupational exposure to low doses of ionizing radiation and cataract development: a systematic literature review and perspectives on future studies

Maternal occupational exposure to ionizing radiation and birth defects

Modification of radiation-induced oral mucositis (mouse) by adult stem cell therapy: single-dose irradiation

Dose and dose-rate effects of ionizing radiation: a discussion in the light of radiological protection

Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study