NDLI: Modification of radiation-induced oral mucositis (mouse) by adult stem cell therapy: single-dose irradiation

Content Provider	Springer Nature Link
Author	Schmidt, Margret Piro Hussong, Aline Siegemund, Annett Gabriel, Peggy Dörr, Wolfgang
Copyright Year	2014
Abstract	Early oral mucositis occurs in response to accidental upper partial body exposure as well as to radiotherapy in the head-and-neck region. This study was initiated to define the potential of mobilization of endogenous bone marrow (BM) stem cells by rHuG-CSF or of bone marrow transplantation (BMT) to reduce the effect of single-dose irradiation on mouse oral epithelium. A 3 × 3 mm2 area of the lower tongue surface of mice was irradiated with graded single doses (day 0). Mucosal ulceration was used as the endpoint for dose–response analyses. Stem cells were mobilized by rHuG-CSF (8 times/4 days), timed to achieve a maximum of circulating stem cells on days 0, +1, +4, +8 or +10. Alternatively, syngeneic BM was transplanted on these days. The ED50 (dose at which ulceration is expected in 50 % of the animals) for irradiation alone was 11.9 ± 3.4 Gy. Mobilization of stem cells with a maximum of circulating stem cells on days +4, +8 or +10 significantly increased the ED50 to 25.5 ± 10.1, 23.5 ± 10.1 and 26.5 ± 13.0 Gy. In contrast, a maximum of circulating stem cells on day 0 or day +1 had no effect. BMT did not result in a significant change in isoeffective doses in any of the protocols. In conclusion, the response of oral mucosal epithelium to a single-radiation exposure can be significantly reduced by post-exposure mobilization, but not by transplantation, of BM stem cells.
Starting Page	629
Ending Page	634
Page Count	6
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	53
Issue Number	4
e-ISSN	14322099
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-06-15
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Oral mucosa Irradiation Stem cell mobilization Bone marrow transplantation Mouse model Biophysics and Biological Physics Effects of Radiation/Radiation Protection Environmental Physics Environmental Monitoring/Analysis Ecosystems
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

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