NDLI: Boron neutron capture therapy (BNCT) for liver metastasis in an experimental model: dose–response at five-week follow-up based on retrospective dose assessment in individual rats

Content Provider	Springer Nature Link
Author	Pozzi, Emilia C. C. Trivillin, Verónica A. Colombo, Lucas L. Monti Hughes, Andrea Thorp, Silvia I. Cardoso, Jorge E. Garabali, Marcela A. Molinari, Ana J. Heber, Elisa M. Curotto, Paula Miller, Marcelo Itoiz, Maria E. Aromando, Romina F. Nigg, David W. Schwint, Amanda E.
Copyright Year	2013
Abstract	Boron neutron capture therapy (BNCT) was proposed for untreatable colorectal liver metastases. Employing an experimental model of liver metastases in rats, we recently demonstrated that BNCT mediated by boronophenylalanine (BPA-BNCT) at 13 Gy prescribed to tumor is therapeutically useful at 3-week follow-up. The aim of the present study was to evaluate dose–response at 5-week follow-up, based on retrospective dose assessment in individual rats. BDIX rats were inoculated with syngeneic colon cancer cells DHD/K12/TRb. Tumor-bearing animals were divided into three groups: BPA-BNCT (n = 19), Beam only (n = 8) and Sham (n = 7) (matched manipulation, no treatment). For each rat, neutron flux was measured in situ and boron content was measured in a pre-irradiation blood sample for retrospective individual dose assessment. For statistical analysis (ANOVA), individual data for the BPA-BNCT group were pooled according to absorbed tumor dose, BPA-BNCT I: 4.5–8.9 Gy and BPA-BNCT II: 9.2–16 Gy. At 5 weeks post-irradiation, the tumor surface area post-treatment/pre-treatment ratio was 12.2 ± 6.6 for Sham, 7.8 ± 4.1 for Beam only, 4.4 ± 5.6 for BPA-BNCT I and 0.45 ± 0.20 for BPA-BNCT II; tumor nodule weight was 750 ± 480 mg for Sham, 960 ± 620 mg for Beam only, 380 ± 720 mg for BPA-BNCT I and 7.3 ± 5.9 mg for BPA-BNCT II. The BPA-BNCT II group exhibited statistically significant tumor control with no contributory liver toxicity. Potential threshold doses for tumor response and significant tumor control were established at 6.1 and 9.2 Gy, respectively.
Starting Page	481
Ending Page	491
Page Count	11
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	52
Issue Number	4
e-ISSN	14322099
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-09-29
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Boron neutron capture therapy BNCT Liver metastasis Liver metastasis experimental model BDIX rats DHD/K12/TRb cells Biophysics and Biological Physics Effects of Radiation/Radiation Protection Environmental Physics Environmental Monitoring/Analysis Ecosystems
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

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