NDLI: Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat

Content Provider	Springer Nature Link
Author	Oršolić, Nada Goluža, Eleora Đikić, Domagoj Lisičić, Duje Sašilo, Kristijan Rođak, Edi Jeleč, Želko Lazarus, Maja Vihnanek Orct, Tatjana
Copyright Year	2013
Abstract	Reactive oxygen species play a role in a number of degenerative conditions including osteoporosis. Flavonoids as phyto-oestrogens exert physiological effects against oxidative stress diseases. We developed a retinoic acid-induced bone loss model of rats to assess whether flavonoids and alendronate as positive control have role against oxidative stress and mineral contents in osteoporosis in vivo.Three-month-old female rats of the Y59 strain were given quercetin, chrysin, naringenin (100 mg kg−1) or alendronate (40 mg kg−1, a positive control) immediately before retinoic acid treatment (80 mg kg−1) once daily for 14 days by a single intragastric (i.g.) application. In the second part of the study, we assessed the effect of those flavonoids on the skeletal system of healthy rats using single i.g. application on the respective flavonoids during 14 days. Twenty-four hours after the treatment, we analysed bone mineral density and the total content of bone calcium and phosphorus in the femur, the geometric and physical characteristics of thigh bones and lipid peroxidation and glutathione levels of liver and kidney cells.All flavonoids improved the decrease in bone weight coefficient, the length and the diameter of the bone, the content of bone ash and calcium and phosphorus content induced by retinoic acid. Chrysin and quercetin showed promise as preventive agents. Flavonoids were superior to alendronate according to some criteria.These results suggest that the dietary flavonoids could reduce retinoic acid-induced oxidative stress and bone loss and that flavonoids may be useful therapeutics for prevention of skeletal diseases.
Starting Page	1217
Ending Page	1227
Page Count	11
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	53
Issue Number	5
e-ISSN	14366215
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-11-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Flavonoids Retinoic acid Bone loss prevention Oxidative stress Rat Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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