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| Content Provider | Springer Nature Link |
|---|---|
| Author | Alavi Naeini, A. M. Elmadfa, I. Djazayery, A. Barekatain, M. Aghaye Ghazvini, M. R. Djalali, M. Feizi, A. |
| Copyright Year | 2013 |
| Abstract | This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran.About 256 elderly with mild cognitive impairment, aged 60–75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year.Demographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined.Antioxidant supplementation reduced malondialdehyde level (P < 0.001) and raised total antioxidant capacity (P < 0.001) and glutathione (P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged (P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively). Despite significant improvement in most of the oxidative stress biomarkers, antioxidants’ supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected. |
| Starting Page | 1255 |
| Ending Page | 1262 |
| Page Count | 8 |
| File Format | |
| ISSN | 14366207 |
| Journal | European Journal of Nutrition |
| Volume Number | 53 |
| Issue Number | 5 |
| e-ISSN | 14366215 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2013-12-11 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Supplementation The elderly Mild cognitive impairment Vitamin E Vitamin C Nutrition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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