NDLI: Characterization of flounder (Paralichthys olivaceus) FoxD5 and its function in regulating myogenic regulatory factor

Content Provider	Springer Nature Link
Author	Tan, Xungang Zhang, Yuqing Sun, Wei Zhang, Peijun Xu, Yongli
Copyright Year	2012
Abstract	As one member of winged helix domain transcription factors, FoxD5 was reported to be a trunk organizer. Recent study showed that zebrafish foxd5 is expressed in the somites. To further understand the function of FoxD5 in fish muscle development, the FoxD5 gene was isolated from flounder. Its expression pattern was analyzed by in situ hybridization, while its function in regulating myogenic regulatory factor, MyoD, was analyzed by ectopic expression. It showed that flounder FoxD5 was firstly expressed in the tailbud, adaxial cells, and neural plate of the head. In flounder embryo, FoxD5 is expressed not only in forebrain but also in somite cells that will form muscle in the future. When flounder FoxD5 was over-expressed in zebrafish by microinjection, the expression of zebrafish MyoD in the somites was reduced, suggesting that FoxD5 is involved in myogenesis by regulating the expression of MyoD.
Starting Page	286
Ending Page	294
Page Count	9
File Format	PDF
ISSN	02544059
Journal	Chinese Journal of Oceanology and Limnology
Volume Number	30
Issue Number	2
e-ISSN	19935005
Language	English
Publisher	SP Science Press
Publisher Date	2012-03-01
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	flounder FoxD5 muscle over-expression in situ hybridization myogenic regulatory factor Oceanography
Content Type	Text
Resource Type	Article
Subject	Water Science and Technology Oceanography

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