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| Content Provider | Springer Nature Link |
|---|---|
| Author | Rosario Meléndez, Roselin Ouimet, Michelle A. Uhrich, Kathryn E. |
| Copyright Year | 2012 |
| Abstract | The formulation of salicylate-based poly(anhydride-ester) (PAE) microspheres was optimized by altering polymer concentration and homogenization speed to improve the overall morphology. The microspheres were prepared using three salicylate-based PAEs with different chemical compositions comprised of either a heteroatomic, linear aliphatic, or branched aliphatic moiety. These PAEs broadened the range of complete salicylic acid release to now include days, weeks, and months. The molecular weight (M w ), polydispersity index (PDI) and glass transition temperature (T g) of the formulated polymers were compared to the unformulated polymers. In general, the M w and PDI exhibited decreased and increased values, respectively, after formulation, whereas the T g changes did not follow a specific trend. Microsphere size and morphology were determined using scanning electron microscopy. These microspheres exhibited smooth surfaces, no aggregation, and size distributions ranging from 2 to 34 μm in diameter. In vitro release studies of the chemically incorporated salicylic acid displayed widely tunable release profiles. |
| Starting Page | 343 |
| Ending Page | 351 |
| Page Count | 9 |
| File Format | |
| ISSN | 01700839 |
| Journal | Polymer Bulletin |
| Volume Number | 70 |
| Issue Number | 1 |
| e-ISSN | 14362449 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-09-07 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Drug delivery Microspheres Salicylic acid Biodegradable Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics |
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