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  1. Springer Seminars in Immunopathology
  2. Springer Seminars in Immunopathology : Volume 29
  3. Springer Seminars in Immunopathology : Volume 29, Issue 4, November 2007
  4. Complement in glomerular injury
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Springer Seminars in Immunopathology : Volume 39
Springer Seminars in Immunopathology : Volume 38
Springer Seminars in Immunopathology : Volume 37
Springer Seminars in Immunopathology : Volume 36
Springer Seminars in Immunopathology : Volume 35
Springer Seminars in Immunopathology : Volume 34
Springer Seminars in Immunopathology : Volume 33
Springer Seminars in Immunopathology : Volume 32
Springer Seminars in Immunopathology : Volume 31
Springer Seminars in Immunopathology : Volume 30
Springer Seminars in Immunopathology : Volume 29
Springer Seminars in Immunopathology : Volume 29, Issue 4, November 2007
Glomerulonephritis : Introduction
Role of T cells and dendritic cells in glomerular immunopathology
B cells in glomerulonephritis: focus on lupus nephritis
Leukocytes in glomerular injury
Complement in glomerular injury
Modulation of glomerulosclerosis
Infection and glomerulonephritis
Minimal change nephropathy and focal segmental glomerulosclerosis
Immunopathogenesis of IgAN
Target antigens and nephritogenic antibodies in membranous nephropathy: of rats and men
Anti-neutrophil cytoplasmic (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies in necrotizing and crescentic glomerulonephritis
Springer Seminars in Immunopathology : Volume 29, Issue 3, September 2007
Springer Seminars in Immunopathology : Volume 29, Issue 2, June 2007
Springer Seminars in Immunopathology : Volume 29, Issue 1, April 2007
Springer Seminars in Immunopathology : Volume 28
Springer Seminars in Immunopathology : Volume 27
Springer Seminars in Immunopathology : Volume 26
Springer Seminars in Immunopathology : Volume 25
Springer Seminars in Immunopathology : Volume 24
Springer Seminars in Immunopathology : Volume 23
Springer Seminars in Immunopathology : Volume 22
Springer Seminars in Immunopathology : Volume 21
Springer Seminars in Immunopathology : Volume 20
Springer Seminars in Immunopathology : Volume 19
Springer Seminars in Immunopathology : Volume 18

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Complement in glomerular injury

Content Provider Springer Nature Link
Author Berger, Stefan P. Daha, Mohamed R.
Copyright Year 2007
Abstract In recent years, research into the role of complement in the immunopathogenesis of renal disease has broadened our understanding of the fragile balance between the protective and harmful functions of the complement system. Interventions into the complement system in various models of immune-mediated renal disease have resulted in both favourable and unfavourable effects and will allow us to precisely define the level of the complement cascade at which a therapeutic intervention will result in an optimal effect. The discovery of mutations of complement regulatory molecules has established a role of complement in the haemolytic uremic syndrome and membranoproliferative glomerulonephritis, and genotyping for mutations of the complement system are already leaving the research laboratory and have entered clinical practice. These clinical discoveries have resulted in the creation of relevant animal models which may provide crucial information for the development of highly specific therapeutic agents. Research into the role of complement in proteinuria has helped to understand pathways of inflammation which ultimately lead to renal failure irrespective of the underlying renal disease and is of major importance for the majority of renal patients. Complement science is a highly exciting area of translational research and hopefully will result in meaningful therapeutic advances in the near future.
Starting Page 375
Ending Page 384
Page Count 10
File Format PDF
ISSN 18632297
Journal Springer Seminars in Immunopathology
Volume Number 29
Issue Number 4
e-ISSN 18632300
Language English
Publisher Springer-Verlag
Publisher Date 2007-09-28
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Glomerulonephritis Hemolytic uremic syndrome Complement Immune complexes Internal Medicine Immunology
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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