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| Content Provider | Springer Nature Link |
|---|---|
| Author | Berger, Stefan P. Daha, Mohamed R. |
| Copyright Year | 2007 |
| Abstract | In recent years, research into the role of complement in the immunopathogenesis of renal disease has broadened our understanding of the fragile balance between the protective and harmful functions of the complement system. Interventions into the complement system in various models of immune-mediated renal disease have resulted in both favourable and unfavourable effects and will allow us to precisely define the level of the complement cascade at which a therapeutic intervention will result in an optimal effect. The discovery of mutations of complement regulatory molecules has established a role of complement in the haemolytic uremic syndrome and membranoproliferative glomerulonephritis, and genotyping for mutations of the complement system are already leaving the research laboratory and have entered clinical practice. These clinical discoveries have resulted in the creation of relevant animal models which may provide crucial information for the development of highly specific therapeutic agents. Research into the role of complement in proteinuria has helped to understand pathways of inflammation which ultimately lead to renal failure irrespective of the underlying renal disease and is of major importance for the majority of renal patients. Complement science is a highly exciting area of translational research and hopefully will result in meaningful therapeutic advances in the near future. |
| Starting Page | 375 |
| Ending Page | 384 |
| Page Count | 10 |
| File Format | |
| ISSN | 18632297 |
| Journal | Springer Seminars in Immunopathology |
| Volume Number | 29 |
| Issue Number | 4 |
| e-ISSN | 18632300 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2007-09-28 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Glomerulonephritis Hemolytic uremic syndrome Complement Immune complexes Internal Medicine Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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