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  1. Springer Seminars in Immunopathology
  2. Springer Seminars in Immunopathology : Volume 29
  3. Springer Seminars in Immunopathology : Volume 29, Issue 4, November 2007
  4. Immunopathogenesis of IgAN
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Springer Seminars in Immunopathology : Volume 39
Springer Seminars in Immunopathology : Volume 38
Springer Seminars in Immunopathology : Volume 37
Springer Seminars in Immunopathology : Volume 36
Springer Seminars in Immunopathology : Volume 35
Springer Seminars in Immunopathology : Volume 34
Springer Seminars in Immunopathology : Volume 33
Springer Seminars in Immunopathology : Volume 32
Springer Seminars in Immunopathology : Volume 31
Springer Seminars in Immunopathology : Volume 30
Springer Seminars in Immunopathology : Volume 29
Springer Seminars in Immunopathology : Volume 29, Issue 4, November 2007
Glomerulonephritis : Introduction
Role of T cells and dendritic cells in glomerular immunopathology
B cells in glomerulonephritis: focus on lupus nephritis
Leukocytes in glomerular injury
Complement in glomerular injury
Modulation of glomerulosclerosis
Infection and glomerulonephritis
Minimal change nephropathy and focal segmental glomerulosclerosis
Immunopathogenesis of IgAN
Target antigens and nephritogenic antibodies in membranous nephropathy: of rats and men
Anti-neutrophil cytoplasmic (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies in necrotizing and crescentic glomerulonephritis
Springer Seminars in Immunopathology : Volume 29, Issue 3, September 2007
Springer Seminars in Immunopathology : Volume 29, Issue 2, June 2007
Springer Seminars in Immunopathology : Volume 29, Issue 1, April 2007
Springer Seminars in Immunopathology : Volume 28
Springer Seminars in Immunopathology : Volume 27
Springer Seminars in Immunopathology : Volume 26
Springer Seminars in Immunopathology : Volume 25
Springer Seminars in Immunopathology : Volume 24
Springer Seminars in Immunopathology : Volume 23
Springer Seminars in Immunopathology : Volume 22
Springer Seminars in Immunopathology : Volume 21
Springer Seminars in Immunopathology : Volume 20
Springer Seminars in Immunopathology : Volume 19
Springer Seminars in Immunopathology : Volume 18

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Immunopathogenesis of IgAN

Content Provider Springer Nature Link
Author Barratt, Jonathan Smith, Alice C. Molyneux, Karen Feehally, John
Copyright Year 2007
Abstract The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a complete understanding of the pathogenesis of IgAN has meant that there is still no treatment known to modify mesangial deposition of IgA. Increasing evidence, however, supports the importance of IgA-containing immune complex formation as a pivotal factor driving mesangial IgA deposition and triggering of glomerular injury. A number of potentially important changes to the IgA1 molecule have been identified in IgAN, which may contribute to immune complex formation. These changes suggest that the polymeric IgA1 that deposits in IgA nephropathy is derived from mucosally primed plasma cells. The presence of this IgA in the circulation reflects displacement of mucosal B lineage cells to systemic sites and may be the result of mishoming of lymphocytes trafficking along the mucosa–bone marrow axis.
Starting Page 427
Ending Page 443
Page Count 17
File Format PDF
ISSN 18632297
Journal Springer Seminars in Immunopathology
Volume Number 29
Issue Number 4
e-ISSN 18632300
Language English
Publisher Springer-Verlag
Publisher Date 2007-09-13
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Glomerulonephritis O-Glycosylation Lymphocyte homing Mesangial cells IgA immune complexes Internal Medicine Immunology
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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